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- Table of Contents
Facts about Insulin-induced gene 2 protein.
Capable of keeping the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs into the Golgi. Appears to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Human | |
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Gene Name: | INSIG2 |
Uniprot: | Q9Y5U4 |
Entrez: | 51141 |
Belongs to: |
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INSIG family |
INSIG2 membrane protein; INSIG-2; insulin induced gene 2; insulin induced protein 2; insulin-induced gene 2 protein; MGC26273
Mass (kDA):
24.778 kDA
Human | |
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Location: | 2q14.1-q14.2 |
Sequence: | 2; NC_000002.12 (118088418..118110997) |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 12242332 by Yabe D., et al. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
PMID: 16606821 by Gong Y., et al. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.