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Facts about Interleukin-11 receptor subunit alpha-1.
Receptor for interleukin-11.
The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission.The IL11/IL11RA/IL6ST complex might be involved in the control of proliferation and/or distinction of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.
| Mouse | |
|---|---|
| Gene Name: | Il11ra1 |
| Uniprot: | Q64385 |
| Entrez: | 16157 |

| Belongs to: |
|---|
| type I cytokine receptor family |

Interleukin-11 receptor subunit alpha-1
Mass (kDA):
46.655 kDA

| Mouse | |
|---|---|
| Location: | 4 A5|4 21.94 cM |
| Sequence: | 4; |
Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo.

PMID: 7813775 by Neuhaus H., et al. etl2, a novel putative type-1 cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential.
PMID: 7957045 by Hilton D.J., et al. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.