JADE2 Antibodies

AND JADE2 ELISA kits, JADE2 Proteins

Many biological assays use antibodies to detect JADE2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JADE2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JADE2 antibodies...

We validate the specificity of these antibodies to JADE2 by testing them on tissues known to express JADE2 positively and negatively. Browse below to find the JADE2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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JADE2 Infographic by Boster Bio

All JADE2 Products

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PHF15 (JADE2) (NM_015288) Human Over-expression Lysate

Human

$628
Cat # LS023338
20 µg, 100 µg

Anti-PHF15/JADE2 Antibody Picoband®

Western blot analysis of PHF15/JADE2 using anti-PHF15/JADE2 antibody (A12993-1)

Human

ELISA, WB

$370
Cat # A12993-1
100 µg/vial

JADE2 Overview

Facts about E3 ubiquitin-protein ligase Jade-2.

JADE2 3D structure. Source: alphafold

E3 ubiquitin-protein ligase Jade-2 (JADE2)

Part of the HBO1 complex that has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the majority of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin- protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020).

Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).

Gene Information

Human
Gene Name:	JADE2
Uniprot:	Q9NQC1
Entrez:	23338

Family

Belongs to:

JADE family

Alternative Names

E3 ubiquitin-protein ligase Jade-2

Molecular Weight

Mass (kDA):
87.466 kDA

Genomic Context


Human

Location:	5q31.1
Sequence:	5; NC_000005.10 (134524153..134583228)

Interacting Proteins

GORASP2
ING5

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JADE2

References

PMID: 12693554 by Jikuya H., et al. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

PMID: 14612400 by Tzouanacou E., et al. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.