E3 ubiquitin-protein ligase Jade-2 (JADE2)

Part of the HBO1 complex that has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the majority of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin- protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020).

Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).