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- Table of Contents
Facts about Histone acetyltransferase KAT6A.
May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at'Lys-120' and'Lys-382' and controls its transcriptional activity via association with PML.
Human | |
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Gene Name: | KAT6A |
Uniprot: | Q92794 |
Entrez: | 7994 |
Belongs to: |
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MYST (SAS/MOZ) family |
EC 2.3.1.48; EC 3.1.26.4; histone acetyltransferase MYST3; KAT6A; MGC167033; MOZMonocytic leukemia zinc finger protein; MYST histone acetyltransferase (monocytic leukemia) 3; MYST-3; runt-related transcription factor binding protein 2; Runt-related transcription factor-binding protein 2; RUNXBP2; Zinc finger protein 220; ZNF220MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
Mass (kDA):
225.028 kDA
Human | |
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Location: | 8p11.21 |
Sequence: | 8; NC_000008.11 (41929479..42051988, complement) |
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Recruited into PML body after DNA damage.
PMID: 8782817 by Borrow J., et al. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.
PMID: 9558366 by Carapeti M., et al. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.