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KCNB1 Antibodies
AND KCNB1 ELISA kits, KCNB1 Proteins
Many biological assays use antibodies to detect KCNB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNB1 antibodies...
Designing a Western blot for KCNB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCNB1 Western Blot GuideKCNB1 Infographic by Boster Bio
All KCNB1 Products
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KCNB1 Overview
Facts about Potassium voltage-gated channel subfamily B member 1.
Potassium voltage-gated channel subfamily B member 1 (KCNB1)
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the mind, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, length and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216).
Plays also a part in the regulation of exocytosis independently of its electric function (By similarity). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNB1 |
| Uniprot: | Q14721 |
| Entrez: | 3745 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
Potassium voltage-gated channel subfamily B member 1
Molecular Weight
Mass (kDA):
95.878 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.13 |
| Sequence: | 20; NC_000020.11 (49363877..49484033, complement) |
Tissue Specificity
Expressed in neocortical pyramidal cells (PubMed:24477962). Expressed in pancreatic beta cells (at protein level) (PubMed:12403834, PubMed:14988243). Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland (PubMed:19074135). Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra (PubMed:19074135).
Subcellular Localizations
Cell membrane. Perikaryon. Cell projection, axon. Cell projection, dendrite. Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse. Cell junction, synapse, synaptosome. Lateral cell membrane. Cell membrane, sarcolemma. Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed:24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the s
Diseases
- Epileptic encephalopathy, early infantile, 26 (EIEE26)
PTMs
- Isopeptide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNB1
bosterbio.com/bosterbio-gene-info-cards/KCNB1
References
PMID: 8081723 by Albrecht B., et al. Cloning and characterization of a human delayed rectifier potassium channel gene.
PMID: 1283219 by Ikeda S.R., et al. Heterologous expression of the human potassium channel Kv2.1 in clonal mammalian cells by direct cytoplasmic microinjection of cRNA.