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- Table of Contents
KCNH1 Antibodies
AND KCNH1 ELISA kits, KCNH1 Proteins
Many biological assays use antibodies to detect KCNH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNH1 antibodies...
Designing a Western blot for KCNH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCNH1 Western Blot GuideKCNH1 Infographic by Boster Bio
All KCNH1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01036-3
100 μg/vial
Cat # A01036-3
100 μg/vial
KCNH1 Overview
Facts about Potassium voltage-gated channel subfamily H member 1.
Potassium voltage-gated channel subfamily H member 1 (KCNH1)
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152).
Mediates IK(NI) present in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, specifically adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNH1 |
| Uniprot: | O95259 |
| Entrez: | 3756 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
EAG channel 1; EAG1; EAGeag1; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; hEAG1; h-eageag; Kv10.1; MGC142269; potassium channel, voltage-gated, subfamily H, member 1; potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; Voltage-gated potassium channel subunit Kv10.1
Molecular Weight
Mass (kDA):
111.423 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.2 |
| Sequence: | 1; NC_000001.11 (210678314..211134148, complement) |
Tissue Specificity
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Early endosome membrane. Perinuclear KCNH1 is located to NPC-free islands.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cardiac Arrhythmia
- Long Qt Syndrome
- Carcinoma
- Neoplasm Metastasis
- Adenocarcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Torsades De Pointes
Interacting Proteins
- FASTKD5
- SDCBP
- WDYHV1
Pathways
- Cell Proliferation
- Cell Cycle
- Reverse Transcription
- Cell Growth
- Localization
- Cell Migration
- Cell Motility
- Regulation Of Cell Proliferation
- Angiogenesis
- Pathogenesis
- Rna Interference
- Secretion
- Oxygen Homeostasis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNH1
bosterbio.com/bosterbio-gene-info-cards/KCNH1
References
PMID: 9738473 by Occhiodoro T., et al. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion.
PMID: 10523298 by Pardo L.A., et al. Oncogenic potential of EAG K(+) channels.