KDM4B Antibodies

AND KDM4B ELISA kits, KDM4B Proteins

Many biological assays use antibodies to detect KDM4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM4B antibodies...

We validate the specificity of these antibodies to KDM4B by testing them on tissues known to express KDM4B positively and negatively. Browse below to find the KDM4B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for KDM4B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the KDM4B Western Blot Guide

KDM4B Infographic by Boster Bio

All KDM4B Products

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Specificity

Applications

Price

Anti-KDM4B / JMJD2B Rabbit Monoclonal Antibody

Western blot analysis of KDM4B using anti-KDM4B antibody (M04127)

IHC analysis of KDM4B using anti-KDM4B antibody (M04127)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M04127
100 μl/vial

KDM4B (NM_015015) Human Over-expression Lysate

Human

$960
Cat # LS023030
20 µg, 100 µg

KDM4B Overview

Facts about Lysine-specific demethylase 4B.

KDM4B 3D structure. Source: alphafold

Lysine-specific demethylase 4B (KDM4B)

Histone demethylase that especially demethylates'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3'Lys-4', H3'Lys-27', H3'Lys-36' nor H4'Lys-20'.

Only able to demethylate trimethylated H3'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

Gene Information

Human
Gene Name:	KDM4B
Uniprot:	O94953
Entrez:	23030

Family

Belongs to:

JHDM3 histone demethylase family

Alternative Names

EC 1.14.11; FLJ44906; JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2BEC 1.14.11.-; jumonji domain containing 2B; Jumonji domain-containing protein 2B; KIAA0876lysine-specific demethylase 4B; lysine (K)-specific demethylase 4B

Molecular Weight

Mass (kDA):
121.897 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (4969087..5153603)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Hypoxia
Mammary Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Carcinogenesis
Anoxia
Leukemia
Stomach Neoplasms
Instabilities, Chromosomal

Malignant Neoplasm Of Kidney
Tumor Progression
Von Hippel-lindau Syndrome
Malignant Neoplasm Of Urinary Bladder
Malignant Neoplasm Of Lung
Multiple Myeloma
Osteoporosis

Pathways

Methylation
Cell Cycle
Cell Proliferation
Histone Methylation
Demethylation
Cell Cycle Arrest
Pathogenesis
Aging
Histone Modification
Mammary Gland Development
Chromosome Segregation
Spermatogenesis
Cell Division

Histone Acetylation
Chromatin Remodeling
Oncogenesis
Gland Development
Response To Hypoxia
Dna Methylation
Histone Demethylation

PTMs

Methylation
Demethylation

Phosphorylation
Reduction

Acetylation

Research Areas

Chromatin Research
Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM4B

References

PMID: 15927959 by Gray S.G., et al. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PMID: 16603238 by Whetstine J.R., et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.