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- Table of Contents
KDM6A Antibodies
AND KDM6A ELISA kits, KDM6A Proteins
Many biological assays use antibodies to detect KDM6A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM6A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM6A antibodies...
Designing a Western blot for KDM6A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KDM6A Western Blot GuideKDM6A Infographic by Boster Bio
All KDM6A Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01286-2
100 μg/vial
Cat # A01286-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, WB
$405
Cat # A01286
100ul
Cat # A01286
100ul
KDM6A Overview
Facts about Lysine-specific demethylase 6A.
Lysine-specific demethylase 6A (KDM6A)
Histone demethylase that specifically demethylates'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated although not monomethylated H3'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849).
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).
Gene Information
| Human | |
|---|---|
| Gene Name: | KDM6A |
| Uniprot: | O15550 |
| Entrez: | 7403 |
Family
| Belongs to: |
|---|
| UTX family |
Alternative Names
bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeatprotein (UTX)); bA386N14.2; DKFZp686A03225; EC 1.14.11; EC 1.14.11.-; Histone demethylase UTX; KABUK2; KDM6A; Lysine (K)specific Demethylase 6A; Lysine (K)-specific Demethylase 6A; MGC141941; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously transcribed tetratricopeptide repeat, X chromosome; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; Ubiquitously-tra
Molecular Weight
Mass (kDA):
154.177 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.3 |
| Sequence: | X; NC_000023.11 (44873175..45112779) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Renal Cell Carcinoma
- Kabuki Make-up Syndrome
- Von Hippel-lindau Syndrome
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Kidney Neoplasm
- Myeloid Leukemia
- Acute Promyelocytic Leukemia
Pathways
- Demethylation
- Methylation
- Pathogenesis
- Chromatin Modification
- Cell Development
- Regulation Of Gene Expression
- Histone Modification
- Localization
- Cell Cycle Arrest
- Drug Resistance
- Germ Cell Development
- Reverse Transcription
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM6A
bosterbio.com/bosterbio-gene-info-cards/KDM6A
References
PMID: 9381176 by Lahn B.T., et al. Functional coherence of the human Y chromosome.
PMID: 17500065 by Cho Y.-W., et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.