Kelch-like protein 3 Antibodies

AND KLHL3 ELISA kits, Kelch-like protein 3 Proteins

Many biological assays use antibodies to detect Kelch-like protein 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 3 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 3 by testing them on tissues known to express KLHL3 positively and negatively. Browse below to find the KLHL3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLHL3 Infographic by Boster Bio

All KLHL3 Products

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KLHL3 (NM_017415) Human Recombinant Protein

Coomassie blue staining of purified KLHL3 protein

$1062
Cat # PROTQ9UH77
20 µg

KLHL3 (NM_017415) Human Over-expression Lysate

Human

$960
Cat # LS026249
20 µg, 100 µg

Anti-KLHL3 Antibody

Human, Mouse, Rat

ELISA, IP, IHC, WB

$370
Cat # A05117-2
100 μl/vial

KLHL3 Overview

Facts about Kelch-like protein 3.

KLHL3 3D structure. Source: alphafold

Kelch-like protein 3 (KLHL3)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031).

The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). .

Gene Information

Human
Gene Name:	KLHL3
Uniprot:	Q9UH77
Entrez:	26249

Family

Belongs to:

No superfamily

Alternative Names

FLJ40871; kelch-like 3 (Drosophila); kelch-like protein 3; KIAA1129kelch (Drosophila)-like 3; MGC44594

Molecular Weight

Mass (kDA):
64.97 kDA

Genomic Context


Human

Location:	5q31.2
Sequence:	5; NC_000005.10 (137617500..137736089, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cytosol.

Diseases

Pseudohypoaldosteronism
Hypertensive Disease
Myeloid Leukemia
Dysmyelopoietic Syndromes
Malignant Paraganglionic Neoplasm
Leukemia
Pseudohypoaldosteronism, Type Ii
Adrenal Hyperplasia
Liddle Syndrome
Endocrine Hypertension
Metabolic Acidosis
De Novo Mutation
Cardiovascular Diseases

Neoplasms
Loss Of Chromosome 5q
Water-electrolyte Imbalance
Cushing Syndrome
Arthrogryposis Multiplex Congenita, Distal, Type Iia
Acidosis
Conn Syndrome

Interacting Proteins

CUL3

Pathways

Transport
Ion Transport
Oocyte Maturation
Pathogenesis
Excretion
Ion Homeostasis

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLHL3

References

PMID: 10843806 by Lai F., et al. Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.

PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.