KCNN1 Antibodies

AND KCNN1 ELISA kits, KCNN1 Proteins

Many biological assays use antibodies to detect KCNN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNN1 antibodies...

We validate the specificity of these antibodies to KCNN1 by testing them on tissues known to express KCNN1 positively and negatively. Browse below to find the KCNN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNN1 Infographic by Boster Bio

All KCNN1 Products

Product

Figures

Specificity

Applications

Price

Anti-KCNN1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A10307
100ul

KCNN1 (NM_002248) Human Over-expression Lysate

Human

$628
Cat # LS003780
100 µg

KCNN1 Overview

Facts about Small conductance calcium-activated potassium channel protein 1.

KCNN1 3D structure. Source: alphafold

Small conductance calcium-activated potassium channel protein 1 (KCNN1)

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization.

Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Gene Information

Human
Gene Name:	KCNN1
Uniprot:	Q92952
Entrez:	3780

Family

Belongs to:

potassium channel KCNN family

Alternative Names

hSK1; KCa2.1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; SK; SK1; SKCa 1; SKCA1; small conductance calcium-activated potassium channel protein 1

Molecular Weight

Mass (kDA):
59.987 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (17951302..17999121)

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Nervousness
Epilepsy
Insulinoma
Pain
Reperfusion Injury
Mood Disorders
Peripheral Nerve Injuries
Chronic Atrial Fibrillation
Hypoxia
Down Syndrome
Injury To Kidney
Acute Erythroblastic Leukemia
Epilepsy, Reflex

Bladder Neck Obstruction
Neoplasms
Wallerian Degeneration
Chimera Disorder
L1 Acute Lymphoblastic Leukemia
Status Epilepticus
Epilepsy, Temporal Lobe

Pathways

Localization
Secretion
Transport
Insulin Secretion
Synaptic Transmission
Glutamate Secretion
Translation
Cognition

Regulation Of Synaptic Transmission
Reflex

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNN1

References

PMID: 8781233 by Koehler M., et al. Small-conductance, calcium-activated potassium channels from mammalian brain.

PMID: 10516439 by Litt M., et al. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).