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- Table of Contents
Galectin-8 Antibodies
AND LGALS8 ELISA kits, Galectin-8 Proteins
Many biological assays use antibodies to detect Galectin-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Galectin-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Galectin-8 antibodies...
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LGALS8 Infographic by Boster Bio
All LGALS8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A05584-1
100ul
Cat # A05584-1
100ul
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M05584-1
100 μl/vial
Cat # M05584-1
100 μl/vial
Human
$628
Cat # LS003964
20 µg, 100 µg
Cat # LS003964
20 µg, 100 µg
Human
ELISA
$499
Cat # EK2234
96 wells/kit, with removable strips.
Cat # EK2234
96 wells/kit, with removable strips.
LGALS8 Overview
Facts about Galectin-8.
Galectin-8 (LGALS8)
Beta-galactoside-binding lectin that serves as a sensor of membrane damage caused by disease and limits the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; those ligands becoming vulnerable to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts disease by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.
Gene Information
| Human | |
|---|---|
| Gene Name: | LGALS8 |
| Uniprot: | O00214 |
| Entrez: | 3964 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GAL8; Gal-8; galectin 8; Galectin8; Galectin-8; galectin-8g; lectin, galactoside-binding, soluble, 8; LGALS8; PCTA1; PCTA-1Po66 carbohydrate-binding protein; Po66 carbohydrate binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1
Molecular Weight
Mass (kDA):
35.808 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43 |
| Sequence: | 1; NC_000001.11 (236518214..236552981) |
Tissue Specificity
Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Subcellular Localizations
Cytoplasmic vesicle. Cytoplasm, cytosol.
Diseases
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasms
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Prostate
- Inflammation
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
- Cell Invasion
- Neoplasm Metastasis
Interacting Proteins
- APEH
- CALCOCO2
- TAX1BP1
- TGIF1
- TRIM23
Pathways
- Cell Adhesion
- Localization
- Cell Migration
- Immune Response
- Glycosylation
- Endocytosis
- Pathogenesis
- Secretion
- Platelet Activation
- Inflammatory Response
- Translation
- Cell Cycle
- Cell Differentiation
PTMs
- Phosphorylation
- Biotinylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LGALS8
bosterbio.com/bosterbio-gene-info-cards/LGALS8
References
PMID: 8692978 by Su Z.-Z., et al. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.
PMID: 10980616 by Gopalkrishnan R.V., et al. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.