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- Table of Contents
Facts about Galectin-8.
Restricts disease by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.
Human | |
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Gene Name: | LGALS8 |
Uniprot: | O00214 |
Entrez: | 3964 |
Belongs to: |
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No superfamily |
GAL8; Gal-8; galectin 8; Galectin8; Galectin-8; galectin-8g; lectin, galactoside-binding, soluble, 8; LGALS8; PCTA1; PCTA-1Po66 carbohydrate-binding protein; Po66 carbohydrate binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1
Mass (kDA):
35.808 kDA
Human | |
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Location: | 1q43 |
Sequence: | 1; NC_000001.11 (236518214..236552981) |
Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Cytoplasmic vesicle. Cytoplasm, cytosol.
If you're interested in determining if you have breast cancer, you should think about buying a high-affinity antibody against the Galectin-8 protein from Boster Bio. It has been proven to be a powerful biomarker that can help determine a positive prognosis. This antibody is available for Flow Cytometry, IP and IF. It is highly reactive to human, mouse and rat specimens.
Galectin-8 is part of the galectin familia, plays a vital role in angiogenesis and endothelial cell movement. This tandem-repeat protein is secreted through a distinct secretory route. Its functions are varied. For instance this protein hinders cell adhesion and also regulates cell growth and is a key player in the development of cancerous cells.
The cDNA of human galectin-8 comprises two carbohydrate recognition domains that are identical joined by the linker peptide. Both mRNAs are encoded with identical isoforms, three of them are tandem-repeat galectins. Galectin-8 has a differential expression in tumor cells. Although this is not an immediate causal link however, this gene may be involved in the development of various cancers.
The role of Galectin-8 in the formation of bone has been studied in various animal models. Studies on animals have shown that mice bred to produce more galectin-8 have greater activity in osteoblast formation. They also secrete higher levels of soluble RANKL. Galectin-8-overexpressing mice exhibit increased osteoclast activity that results in the reduction of bone mass. This mechanism could mimic osteoporosis in postmenopausal women, or cancerous bone destruction. This protein is a direct effect on osteoprotegerin which is an antagonist for RANKL.
While Galectins are believed to play a significant role in cell migration, their functions in cancer research are not fully understood. They are believed to have an impact on cell survival and migration, and are associated with chemoresistance. Some of these functions related to cancer include cell invasion, migration, and Apoptosis. Other aspects of Galectin function are not yet clear. These findings show the importance of Galectin-8 for the treatment of glioblastoma.
In addition to its role in the treatment of cancer metastasis, Galectin-8 blocks tumor growth and invasion. It also promotes the production of cytokines by bone marrow-derived dendritic cells. Gal-8 deficient mice have significantly lower serum levels. This study highlights the importance of Galectin-8 in the development of cancer. Thus, in cancer Galectin-8 plays a significant player.
A large study in Australia has demonstrated that the Ki67 blood test can be used to determine survival rates in breast cancer patients. The study involved nearly 4350 patients. It utilized a modified intent-to-treat approach. The primary goal of the study was the time taken for the tumor to return regardless of whether it was distant, local, regional or after diagnosis. Secondary clinical endpoints included Relapse-free survival, overall survival, and death due to any reason.
The researchers determined the miRNA expression levels by reading readhiser million miRNAs (RPM) on the GEOD-40525 dataset , using the Agilent-019118 Human miRNA Microarray 2.0 platform. After making multiple comparison adjustments they identified the top ten miRNAs as well as their levels in the validation set.
The research also proved that the DNA of tumors in circulation can be used as a biomarker that can help predict the prognosis of patients diagnosed with breast cancer. Researchers have found that it could be an important indicator to predict the prognosis of a patient, and are now looking into its use in cancer treatment. A number of targeted drugs have been approved for breast cancer treatment such as an immunotherapy that is that is based on p-gp TAM.
The study also showed that 8 miRNAs had a significant impact on the prognosis for patients with TNBC. In two validation sets, the eight miRNAs had high correlations with prognosis. This is a significant improvement over the current TNM staging system and may help clinicians choose the best treatment options for patients at high risk.
Oncotype RS is a multigene test designed for women with hormone receptor positive breast cancer who are in treatment with Tamoxifen. The ROR is determined by the Oncotype RS score. The Oncotype RS scores can be used to classify patients into one of three risk categories: moderate (18-29) medium (30-plus), or high (>30).
Multigene assays are recommended to predict the possibility of recurrence in distant areas following BCI. These tests are recommended for patients suffering from node-negative cancer. However, they will require further testing in retrospective and prospective trials. This is the best way to determine whether you have an excellent prognosis. However, further studies are needed to confirm this.
Flow cytometry samples particles and cells. High-affinity primary antibodies from Boster Bio help to detect these proteins. These antibodies are monoclonal and polyclonal, and they have been frequently referenced in scientific publications for the past 25years. In addition to their high affinity Boster's antibodies are highly compatible with other primary antibodies, allowing for cost-effective, high-throughput analysis.
These antibodies are essential components of experiments and immunoassays. They can be used for numerous purposes, including immunohistochemistry or histopathology. In addition to this they can also be utilized for flow cytometry, which is a method to measure the number of certain cell types of interest. They are highly specific and useful in quantifying and detecting the amount of certain types of cells in tissues.
Boster Biologicals is a leading supplier of antibodies and ELISA kits to detect of various proteins, antigens, and Cytokines. Their expertise and over a decade of experience are confirmed by the trust of over 10,000 scientists around the world. Their Picokine ELISA kits help accelerate the process of discovery in science. The kits are stocked with enough reagents that can be used in 96 tests. They are tested and validated to guarantee high sensitivity and specificity.
The company was established in 1993 and is now one of the largest catalog antibody companies in China. It offers a variety of products, including ELISA kits and Lysates. PicoKine(tm) is their revolutionary platform, utilizes trade secrets to offer high-sensitivity ELISA kit kits. Boster Bio provides a broad assortment of products, including reagents, ELISA kits, controls and extraction kits.
Boster Bio's diverse antibody portfolio includes more than 16,000 antibodies for WB, ELISA, and immunohistochemistry. Boster Bio offers an impressive number of products in these categories that include IHC-optimized antibodies. Their products are validated and tested against panels of more than 250 tissues, untransfected cell lines, and Recombinant proteins. Boster Bio guarantees that each product will perform as promised.
PMID: 8692978 by Su Z.-Z., et al. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.
PMID: 10980616 by Gopalkrishnan R.V., et al. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.