Galectin-8 (LGALS8)

Beta-galactoside-binding lectin that serves as a sensor of membrane damage caused by disease and limits the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; those ligands becoming vulnerable to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).

Restricts disease by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.