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- Table of Contents
Facts about Low-density lipoprotein receptor-related protein 4.
Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex.
| Human | |
|---|---|
| Gene Name: | LRP4 |
| Uniprot: | O75096 |
| Entrez: | 4038 |

| Belongs to: |
|---|
| LDLR family |

CLSS; KIAA0816; low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP10; LRP4; LRP-4; MEGF7LRP10; Multiple epidermal growth factor-like domains 7
Mass (kDA):
212.045 kDA

| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (46854715..46918550, complement) |
Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.
Cell membrane; Single-pass type I membrane protein.





PMID: 9693030 by Nakayama M., et al. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening.
PMID: 20381006 by Li Y., et al. LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.