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- Table of Contents
Galectin-8 Antibodies
AND LGALS8 ELISA kits, Galectin-8 Proteins
Many biological assays use antibodies to detect Galectin-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Galectin-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Galectin-8 antibodies...
Designing a Western blot for Galectin-8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LGALS8 Western Blot GuideLGALS8 Infographic by Boster Bio
All LGALS8 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK2234
96 wells/kit, with removable strips.
Cat # EK2234
96 wells/kit, with removable strips.
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M05584-1
100 μl/vial
Cat # M05584-1
100 μl/vial
Human
$628
Cat # LS003964
20 µg, 100 µg
Cat # LS003964
20 µg, 100 µg
LGALS8 Overview
Facts about Galectin-8.
Galectin-8 (LGALS8)
Beta-galactoside-binding lectin that serves as a sensor of membrane damage caused by disease and limits the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; those ligands becoming vulnerable to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878).
Restricts disease by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.
Gene Information
| Human | |
|---|---|
| Gene Name: | LGALS8 |
| Uniprot: | O00214 |
| Entrez: | 3964 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GAL8; Gal-8; galectin 8; Galectin8; Galectin-8; galectin-8g; lectin, galactoside-binding, soluble, 8; LGALS8; PCTA1; PCTA-1Po66 carbohydrate-binding protein; Po66 carbohydrate binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1
Molecular Weight
Mass (kDA):
35.808 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43 |
| Sequence: | 1; NC_000001.11 (236518214..236552981) |
Tissue Specificity
Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Subcellular Localizations
Cytoplasmic vesicle. Cytoplasm, cytosol.
Diseases
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasms
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Prostate
- Inflammation
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
- Cell Invasion
- Neoplasm Metastasis
Interacting Proteins
- APEH
- CALCOCO2
- TAX1BP1
- TGIF1
- TRIM23
Pathways
- Cell Adhesion
- Localization
- Cell Migration
- Immune Response
- Glycosylation
- Endocytosis
- Pathogenesis
- Secretion
- Platelet Activation
- Inflammatory Response
- Translation
- Cell Cycle
- Cell Differentiation
PTMs
- Phosphorylation
- Biotinylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LGALS8
bosterbio.com/bosterbio-gene-info-cards/LGALS8
References
PMID: 8692978 by Su Z.-Z., et al. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.
PMID: 10980616 by Gopalkrishnan R.V., et al. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.