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- Table of Contents
LRP6 Antibodies
AND LRP6 ELISA kits, LRP6 Proteins
Many biological assays use antibodies to detect LRP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRP6 antibodies...
Designing a Western blot for LRP6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the LRP6 Western Blot GuideLRP6 Infographic by Boster Bio
All LRP6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00970
100 μl/vial
Cat # M00970
100 μl/vial
Human, Mouse
ELISA, IP, IF, IHC, WB
$146
Cat # M00970-1
20μL, 40μL, 100μL, 200μL
Cat # M00970-1
20μL, 40μL, 100μL, 200μL
LRP6 Overview
Facts about Low-density lipoprotein receptor-related protein 6.
Low-density lipoprotein receptor-related protein 6 (LRP6)
Component of the Wnt-Fzd-LRP5-LRP6 complex that activates beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.
The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and degradation of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | LRP6 |
| Uniprot: | O75581 |
| Entrez: | 4040 |
Family
| Belongs to: |
|---|
| LDLR family |
Alternative Names
ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP6; LRP-6
Molecular Weight
Mass (kDA):
180.429 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.2 |
| Sequence: | 12; NC_000012.12 (12116025..12267044, complement) |
Tissue Specificity
Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft. On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Osteoporosis
- Cell Transformation, Neoplastic
- Fracture
- Malignant Neoplasm Of Breast
- Diabetes Mellitus
- Mammary Neoplasms
- Inflammation
- Tissue Adhesions
- Congenital Abnormality
- Bone Diseases
Interacting Proteins
- AMMECR1
- ANTXR1
- Axin1
- Axin1
- CAV1
- DAB2
- DKK1
- Fzd8
- GSK3A
- GSK3B
Pathways
- Cell Proliferation
- Endocytosis
- Localization
- Pathogenesis
- Tissue Homeostasis
- Cell Cycle
- Secretion
- Osteoblast Differentiation
- Gastrulation
- Glycosylation
- Cell Growth
- Bone Resorption
- Transport
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP6
bosterbio.com/bosterbio-gene-info-cards/LRP6
References
PMID: 9704021 by Brown S.D., et al. Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
PMID: 11448771 by Semenov M.V., et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.