Lynx1 Antibodies

AND Lynx1 ELISA kits, Lynx1 Proteins

Many biological assays use antibodies to detect Lynx1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lynx1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lynx1 antibodies...

We validate the specificity of these antibodies to Lynx1 by testing them on tissues known to express Lynx1 positively and negatively. Browse below to find the Lynx1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Lynx1 Infographic by Boster Bio

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Lynx1 Overview

Facts about Ly-6/neurotoxin-like protein 1.

Ly-6/neurotoxin-like protein 1 (Lynx1)

Acts in various cells through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:10402197). The proposed role as modulator of nAChR activity appears to be dependent on the nAChR subtype and stoichiometry, and also to involve an impact on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.

Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excess excitation, and hence neurodegeneration. Enhances desensitization by increasing both the speed and extent of desensitization of alpha- 4:beta-2-containing nAChRs and slowing recovery from desensitization.

Gene Information

Mouse
Gene Name:	Lynx1
Uniprot:	P0DP60
Entrez:	23936

Family

Belongs to:

No superfamily

Alternative Names

Ly-6/neurotoxin-like protein 1

Molecular Weight

Mass (kDA):
12.835 kDA

Genomic Context


Mouse

Location:	15\|15 D3
Sequence:	15;

Tissue Specificity

Expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus (PubMed:10402197, PubMed:11906696). Also expressed in kidney, heart and thymus, but at lower levels than in the brain (PubMed:10402197). Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level) (PubMed:21071629).

PTMs

Disulfide bond
Glycoprotein

GPI-anchor
Lipoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Lynx1

References

PMID: 10402197 by Miwa J.M., et al. Lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS.

PMID: 11906696 by Ibanez-Tallon I., et al. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1.