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- Table of Contents
Facts about Melanoma-associated antigen 3.
Proposed to behave through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
Human | |
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Gene Name: | MAGEA3 |
Uniprot: | P43357 |
Entrez: | 4102 |
Belongs to: |
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No superfamily |
Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3 MAGE-3 antigen; CT1.3; HIP8; MAGE3 MAGEA6; MAGE3; MAGEA3; melanoma antigen family A, 3; melanoma-associated antigen 3; member 3; MGC14613
Mass (kDA):
34.747 kDA
Human | |
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Location: | Xq28 |
Sequence: | X; NC_000023.11 (152698742..152702347) |
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
PMID: 8113684 by Gaugler B., et al. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.
PMID: 8037761 by Ding M., et al. Cloning and analysis of MAGE-1-related genes.