Melanoma-associated antigen C2 (MAGEC2)

Proposed to boost ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation.

Proposed to behave through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. .