MAN2B1 Antibodies

AND MAN2B1 ELISA kits, MAN2B1 Proteins

Many biological assays use antibodies to detect MAN2B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAN2B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAN2B1 antibodies...

We validate the specificity of these antibodies to MAN2B1 by testing them on tissues known to express MAN2B1 positively and negatively. Browse below to find the MAN2B1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAN2B1 Infographic by Boster Bio

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MAN2B1 (NM_000528) Human Recombinant Protein

Coomassie blue staining of purified MAN2B1 protein

$1062
Cat # PROTO00754
20 µg

MAN2B1 Overview

Facts about Lysosomal alpha-mannosidase.

MAN2B1 3D structure. Source: alphafold

Lysosomal alpha-mannosidase (MAN2B1)

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.

Gene Information

Human
Gene Name:	MAN2B1
Uniprot:	O00754
Entrez:	4125

Family

Belongs to:

glycosyl hydrolase 38 family

Alternative Names

alpha B, lysosomal; EC 3.2.1; EC 3.2.1.24; LAMAN; Lysosomal acid alpha-mannosidase; MAN2B1; MANB; Mannosidase alpha class 2B member 1; Mannosidase Alpha-B; mannosidase, alpha, class 2B, member 1

Molecular Weight

Mass (kDA):
113.744 kDA

Genomic Context


Human

Location:	19p13.13
Sequence:	19; NC_000019.10 (12646508..12666777, complement)

Subcellular Localizations

Lysosome.

Diseases

Alpha-mannosidosis
Mannosidase Deficiency Diseases
Infective Disorder
Pfaundler-hurler Syndrome
Weakness
Strabismus
Developmental Delay (disorder)
Ataxia
Dysostoses
Hydrocephalus
Muscle Hypotonia
Psychotic Disorders

Growth Retardation
Mucopolysaccharidoses
Prognathism
Lysosomal Storage Diseases
Leukemia
Acute Promyelocytic Leukemia
Scoliosis, Unspecified

Pathways

Secretion
Transport
Localization
Protein Processing

PTMs

Disulfide bond

Glycoprotein

Zymogen

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAN2B1

References

PMID: 8166692 by Nebes V.L., et al. Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.

PMID: 9158146 by Nilssen O., et al. Alpha-mannosidosis: functional cloning of the lysosomal alpha- mannosidase cDNA and identification of a mutation in two affected siblings.