Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Serine/threonine kinase which functions as an essential component of the MAP kinase signal transduction pathway. Plays an essential part in the cascades of cellular responses evoked by changes in the environment.

Mediates signaling for determination of cell fate like differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.