- Table of Contents
Mediates signaling for determination of cell fate like differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.
|protein kinase superfamily|
|Sequence:||6; NC_000006.12 (136557046..136793098, complement)|
Abundantly expressed in heart and pancreas.
Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
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