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- Table of Contents
MAP3K5 Antibodies
AND MAP3K5 ELISA kits, MAP3K5 Proteins
Many biological assays use antibodies to detect MAP3K5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K5 antibodies...
Designing a Western blot for MAP3K5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MAP3K5 Western Blot GuideMAP3K5 Infographic by Boster Bio
All MAP3K5 Products
Product
Figures
Specificity
Applications
Price
Anti-ASK1/MAP3K5 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00929-3
100 μg/vial
Cat # A00929-3
100 μg/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00929
100 μl
Cat # M00929
100 μl
Human, Mouse
ELISA, IP, IF, IHC, WB
$146
Cat # M00929-1
20μL, 40μL, 100μL, 200μL
Cat # M00929-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2351
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2351
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2350
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2350
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1039
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1039
1 kit, containing one 96-well plate and all necessary reagents
MAP3K5 Overview
Facts about Mitogen-activated protein kinase kinase kinase 5.
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Serine/threonine kinase which functions as an essential component of the MAP kinase signal transduction pathway. Plays an essential part in the cascades of cellular responses evoked by changes in the environment.
Mediates signaling for determination of cell fate like differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K5 |
| Uniprot: | Q99683 |
| Entrez: | 4217 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Apoptosis signal-regulating kinase 1; ASK1; ASK-1; ASK1MEKK 5; EC 2.7.11; MAP/ERK kinase kinase 5; MAP3K5; MAPK/ERK kinase kinase 5; MAPKKK5EC 2.7.11.25; MEK kinase 5; MEKK5; MEKK5apoptosis signal regulating kinase 1; mitogen-activated protein kinase kinase kinase 5
Molecular Weight
Mass (kDA):
154.537 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q23.3 |
| Sequence: | 6; NC_000006.12 (136557046..136793098, complement) |
Tissue Specificity
Abundantly expressed in heart and pancreas.
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Carcinoma
- Physiological Stress
- Neurodegenerative Disorders
- Parkinson Disease
- Hypertrophy
- Tissue Adhesions
- Endoplasmic Reticulum Stress
- Malignant Paraganglionic Neoplasm
- Cardiac Hypertrophy
- Alzheimer's Disease
Interacting Proteins
- AKT1
- APP
- ARRB1
- ARRB2
- CIB1
- DAB2IP
- DAXX
- FAS
- MAP2K3
- Map3k6
Pathways
- Cell Death
- Cell Cycle
- Pathogenesis
- Rna Interference
- Cell Proliferation
- Immune Response
- Programmed Cell Death
- Localization
- Cell Growth
- Cell Adhesion
- Cell Cycle Arrest
- Neuroprotection
- Secretion
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Oxidation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K5
bosterbio.com/bosterbio-gene-info-cards/MAP3K5
References
PMID: 8940179 by Wang X.S., et al. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
PMID: 8974401 by Ichijo H., et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.