MBTPS1 Antibodies

AND MBTPS1 ELISA kits, MBTPS1 Proteins

Many biological assays use antibodies to detect MBTPS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBTPS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBTPS1 antibodies...

We validate the specificity of these antibodies to MBTPS1 by testing them on tissues known to express MBTPS1 positively and negatively. Browse below to find the MBTPS1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBTPS1 Infographic by Boster Bio

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S1P (MBTPS1) (NM_003791) Human Over-expression Lysate

Human

$960
Cat # LS008720
20 µg, 100 µg

MBTPS1 Overview

Facts about Membrane-bound transcription factor site-1 protease.

MBTPS1 3D structure. Source: alphafold

Membrane-bound transcription factor site-1 protease (MBTPS1)

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6.

Cleaves after hydrophobic or smallish residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.

Gene Information

Human
Gene Name:	MBTPS1
Uniprot:	Q14703
Entrez:	8720

Family

Belongs to:

peptidase S8 family

Alternative Names

EC 3.4.21.112; Endopeptidase S1P; KIAA0091MGC138712; membrane-bound transcription factor peptidase, site 1; membrane-bound transcription factor protease, site 1; PCSK8; S1PMGC138711; site-1 protease; SKI1; SKI-1membrane-bound transcription factor site-1 protease; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1

Molecular Weight

Mass (kDA):
117.749 kDA

Genomic Context


Human

Location:	16q23.3-q24.1
Sequence:	16; NC_000016.10 (84053763..84116942, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. May sort to other organelles, including lysosomal and/or endosomal compartments.

Diseases

Liver Diseases
Alcoholic Liver Diseases
Fatty Liver
Atherosclerosis
Steatosis
Hepatomegaly
Infection, Arenavirus
Malignant Neoplasm Of Breast
Hepatitis B
Neoplasm Invasiveness
Carcinoma
Carcinogenesis

Endoplasmic Reticulum Stress
Cardiovascular Diseases
Malignant Neoplasms
Neoplasms
Dental Plaque
Hypocholesterolemia
Mammary Neoplasms

Pathways

Lactation
Parturition
Fibrinolysis
Pigmentation
Response To Alcohol
Receptor Recycling

Pathogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBTPS1

References

PMID: 10944850 by Nakajima T., et al. Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene.

PMID: 10644685 by Toure B.B., et al. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.