Mcf2l Antibodies

AND Mcf2l ELISA kits, Mcf2l Proteins

Many biological assays use antibodies to detect Mcf2l, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mcf2l in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mcf2l antibodies...

We validate the specificity of these antibodies to Mcf2l by testing them on tissues known to express Mcf2l positively and negatively. Browse below to find the Mcf2l antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Mcf2l Infographic by Boster Bio

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Anti-MCF2L Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A08460
100ul

Mcf2l Overview

Facts about Guanine nucleotide exchange factor DBS.

Guanine nucleotide exchange factor DBS (Mcf2l)

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (PubMed:17000758, PubMed:11889037, PubMed:12006984). Seems to lack activity with RAC1.

Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). .

Gene Information

Mouse
Gene Name:	Mcf2l
Uniprot:	Q64096
Entrez:	17207

Family

Belongs to:

MCF2 family

Alternative Names

DBL's big sister; DBS; FLJ12122; guanine nucleotide exchange factor DBS; KIAA0362ARHGEF14; MCF.2 cell line derived transforming sequence-like; MCF2 transforming sequence-like protein; MCF2-transforming sequence-like protein; OST

Molecular Weight

Mass (kDA):
129.113 kDA

Genomic Context


Mouse

Location:	8\|8 A1.1
Sequence:	8;

Tissue Specificity

Expressed at low levels in several hemopoietic cell lines and in thymus and spleen, and at higher levels in other tissues, particularly in brain.

Diseases

Degenerative Polyarthritis
Cell Transformation, Neoplastic
Malignant Neoplasms
Pain
Coagulation Factor Deficiency
Diabetic Nephropathy
Malignant Neoplasm Of Breast
Tumor Progression
Infertility
Arthropathy
Neoplasms
Nervousness
Mammary Neoplasms

Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Cell Invasion
Abnormal Degeneration
Hypoparathyroidism
Kidney Failure, Chronic
Malignant Paraganglionic Neoplasm

Pathways

Localization
Cell Motility
Cell Proliferation
Clathrin-mediated Endocytosis
Transport
Negative Regulation Of Clathrin-mediated Endocytosis
Cell Migration
Brain Development
Immune Response
Spermatogenesis
Replicative Senescence
Translation
Regulation Of Clathrin-mediated Endocytosis

Cell Cycle
Wound Healing
Translational Initiation
Dna Methylation
Endocytosis
Methylation
Senescence

PTMs

Phosphorylation

Acetylation

Prenylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mcf2l

References

PMID: 7862449 by Whitehead I., et al. Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

PMID: 17000758 by Kostenko E.V., et al. Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.