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- Table of Contents
Midkine Antibodies
AND MDK ELISA kits, Midkine Proteins
Many biological assays use antibodies to detect Midkine, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Midkine in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Midkine antibodies...
Designing a Western blot for Midkine? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MDK Western Blot GuideMDK Infographic by Boster Bio
All MDK Products
Product
Figures
Specificity
Applications
Price
Zebrafish
Flow Cytometry, IF, IHC
$470
Cat # DZ41849
200 μl/vial
Cat # DZ41849
200 μl/vial
MDK Overview
Facts about Midkine.
Midkine (MDK)
Developmentally controlled, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation.
Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland growth (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | MDK |
| Uniprot: | P21741 |
| Entrez: | 4192 |
Family
| Belongs to: |
|---|
| pleiotrophin family |
Alternative Names
Amphiregulin-associated protein; ARAP; MDK; MEK; Midgestation and kidney protein; midkine (neurite growth-promoting factor 2); Midkine; MK1; MKARAP; NEGF2; NEGF2FLJ27379; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein
Molecular Weight
Mass (kDA):
15.585 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (46380784..46383837) |
Tissue Specificity
Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Dysplasia
- Tumor Angiogenesis
- Inflammation
- Kidney Diseases
- Neoplasm Metastasis
- Multicystic Dysplastic Kidney
- Mental Disorders
- Tissue Adhesions
Pathways
- Angiogenesis
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Cell Migration
- Localization
- Neurogenesis
- Cell Cycle
- Regulation Of Growth
- Regeneration
- Drug Resistance
- Lung Development
- Cell Division
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MDK
bosterbio.com/bosterbio-gene-info-cards/MDK
References
PMID: 2025291 by Tsutsui J., et al. A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.
PMID: 1768439 by Kretschmer P.J., et al. Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.
6 Publications of Boster Midkine Antibodies & ELISA Kits
- PubMed ID: 10.4274/jcrpe.galenos.2021.2020.0303, Midkine: As a Predictor of Early Diabetic Nephropathy in Children with Type 1 Di...
- PubMed ID: 10.1097/MD.0000000000025112, Serum midkine is a more sensitive predictor for hepatocellular carcinoma than Di...
- PubMed ID: 10.1016/j.biopha.2018.08.061, Midkine downregulation increases the efficacy of quercetin on prostate cancer st...
- PubMed ID: 10.1007/s10637-019-00774-8, Midkine silencing enhances the anti–prostate cancer stem cell activity of the ...
- PubMed ID: 33907088, El-Shayeb AF,El-Habachi NM,Mansour AR,Zaghloul MS.Serum midkine is a more sensit...
- PubMed ID: 18350623, Over-expressed and truncated midkines promote proliferation of BGC823 cells in v...
*More publications can be found for each product on its corresponding product page