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- Table of Contents
Facts about Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B.
Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis.
Human | |
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Gene Name: | MGAT4B |
Uniprot: | Q9UQ53 |
Entrez: | 11282 |
Belongs to: |
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glycosyltransferase 54 family |
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; aminyltransferase; EC 2.4.1.145; GlcNAc-T IVb; GNT-IV; GNT-IVB; isoenzyme B; isozyme B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannosidebeta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannosidebeta-1,4-N-acetylglucosaminyltransfe
Mass (kDA):
63.198 kDA
Human | |
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Location: | 5q35.3 |
Sequence: | 5; NC_000005.10 (179797597..179806977, complement) |
Widely expressed. Strongly overexpressed in pancreatic cancer.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 10372966 by Yoshida A., et al. A novel second isoenzyme of the human UDP-N- acetylglucosamine:alpha1,3-D-mannoside beta1,4-N- acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment.
PMID: 16434023 by Ide Y., et al. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.