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- Table of Contents
MMP24 Antibodies
AND MMP24 ELISA kits, MMP24 Proteins
Many biological assays use antibodies to detect MMP24, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMP24 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMP24 antibodies...
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MMP24 Infographic by Boster Bio
All MMP24 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA2212
100 μg/vial
Cat # PA2212
100 μg/vial
MMP24 Overview
Facts about Matrix metalloproteinase-24.
Matrix metalloproteinase-24 (MMP24)
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia.
Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth.
Gene Information
| Human | |
|---|---|
| Gene Name: | MMP24 |
| Uniprot: | Q9Y5R2 |
| Entrez: | 10893 |
Family
| Belongs to: |
|---|
| peptidase M10A family |
Alternative Names
EC 3.4.24; EC 3.4.24.-; EC 3.4.24.80; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24 (membrane-inserted); matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP24; MMP-24; MT5MMP; MT5-MMP; MT5-MMPMMP25; MT-MMP 5; MTMMP5; MT-MMP5
Molecular Weight
Mass (kDA):
73.231 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.22 |
| Sequence: | 20; NC_000020.11 (35226690..35276998) |
Tissue Specificity
Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
Subcellular Localizations
[Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix. Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.
Diseases
- Cell Invasion
- Neoplasms
- Nervousness
- Neoplasm Metastasis
- Carcinoma
- Malignant Neoplasms
- Pain
- Inflammation
- Tissue Adhesions
- Aneurysm
- Diabetic Nephropathy
- Malignant Neoplasm Of Brain
- Endometriosis, Site Unspecified
Pathways
- Localization
- Proteolysis
- Tissue Remodeling
- Cell Adhesion
- Cell Migration
- Gene Silencing
- Brain Development
- Dna Demethylation
- Dna Methylation
- Neurogenesis
- Dna Methylation Or Demethylation
- Demethylation
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP24
bosterbio.com/bosterbio-gene-info-cards/MMP24
References
PMID: 10363975 by Llano E., et al. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase a overexpressed in brain tumors.
2 Publications of Boster MMP24 Antibodies & ELISA Kits
- PubMed ID: 28990064, Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J. Mol Med Rep. ...
- PubMed ID: 27882817, Yan Li, Lin Li, Ou Zeng, Jun Mao Liu & Jun Yang H2S improves renal fibrosis in S...
*More publications can be found for each product on its corresponding product page