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Transcription factor MafK Antibodies
AND MAFK ELISA kits, Transcription factor MafK Proteins
Many biological assays use antibodies to detect Transcription factor MafK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor MafK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor MafK antibodies...
Designing a Western blot for Transcription factor MafK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MAFK Western Blot GuideMAFK Infographic by Boster Bio
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MAFK Overview
Facts about Transcription factor MafK.
Transcription factor MafK (MAFK)
Because they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they appear to function as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA- binding sites (PubMed:9150357, PubMed:8932385).
Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). .
Gene Information
| Human | |
|---|---|
| Gene Name: | MAFK |
| Uniprot: | O60675 |
| Entrez: | 7975 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
FLJ32205; MafK; MGC71717; NFE2U; transcription factor MafK; ubiquitous (p18); v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K; v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein K; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
Molecular Weight
Mass (kDA):
17.523 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.3 |
| Sequence: | 7; NC_000007.14 (1530702..1543043) |
Subcellular Localizations
Nucleus.
Diseases
- Acute Erythroblastic Leukemia
- Diabetes Mellitus
- Fibrosarcoma
- Neoplasms
- Liver Carcinoma
- Diabetic Nephropathy
- Hepatocarcinogenesis
- Cell Transformation, Neoplastic
- Kidney Diseases
- Drug-induced Liver Injury
- Hepatotoxicity
- Anemia
- Diabetes Mellitus, Non-insulin-dependent
Interacting Proteins
- NFE2L2
Pathways
- Cell Differentiation
- Localization
- Platelet Formation
- Secretion
- Cell Cycle
- Insulin Secretion
- Cell Growth
- Excretion
- Cytokine Secretion
- Hypersensitivity
- Plasma Cell Differentiation
- Regulation Of Gene Expression
- Nuclear Export
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAFK
bosterbio.com/bosterbio-gene-info-cards/MAFK
References
PMID: 9150357 by Toki T., et al. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.
PMID: 8932385 by Johnsen O., et al. Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.