Mxd3 Antibodies

AND Mxd3 ELISA kits, Mxd3 Proteins

Many biological assays use antibodies to detect Mxd3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mxd3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mxd3 antibodies...

We validate the specificity of these antibodies to Mxd3 by testing them on tissues known to express Mxd3 positively and negatively. Browse below to find the Mxd3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Mxd3 Infographic by Boster Bio

All Mxd3 Products

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Specificity

Applications

Price

MAD3 (MXD3) (NM_031300) Human Recombinant Protein

Coomassie blue staining of purified MXD3 protein

$1062
Cat # PROTQ9BW11
20 µg

Anti-MAD3 Rabbit Monoclonal Antibody

Western blot analysis of MAD3 expression in HeLa cell lysate

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # M11285
100 μl/vial

MAD3 (MXD3) (NM_031300) Human Over-expression Lysate

MAD3 (MXD3) Human Over-expression Lysates NM_001142935

Human

$628
Cat # LS083463
20 µg, 100 µg

Mxd3 Overview

Facts about Max dimerization protein 3.

Max dimerization protein 3 (Mxd3)

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'.

Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. .

Gene Information

Mouse
Gene Name:	Mxd3
Uniprot:	Q80US8
Entrez:	17121

Family

Belongs to:

No superfamily

Alternative Names

bHLHc13; Class C basic helix-loop-helix protein 13; MAD3FLJ35523; MAX dimerization protein 3; Max dimerizer 3; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; MGC2383; MYX

Molecular Weight

Mass (kDA):
23.635 kDA

Genomic Context


Mouse

Location:	13 B1\|13 29.8 cM
Sequence:	13;

Tissue Specificity

Expressed only in the proliferating areas of the testis and thymus.

Diseases

Neoplasms
Cell Transformation, Neoplastic
Medulloblastoma
Tumor Progression
Brain Neoplasms
Precancerous Conditions
Testicular Neoplasms
Cerebellar Neoplasms
Mitochondrial Diseases
Situs Ambiguus
Genomic Instability
Neurotoxicity Syndromes
Tumors Of Adrenal Cortex

Granulosa Cell Tumor
Paroxysmal Nocturnal Dyspnea
Maternal Exposure
Nervousness
Pituitary Diseases
Ovarian Neoplasm
Hyperplasia

Pathways

Spindle Checkpoint
Cell Cycle
Cell Proliferation
Mitosis
Chromosome Segregation
Anaphase
Immune Response
Cell Cycle Arrest
Cell Death

Cell Differentiation
Spindle Assembly Checkpoint
B Cell Differentiation
Spindle Assembly

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mxd3

References

PMID: 8521822 by Hurlin P.J., et al. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

PMID: 11154258 by Queva C., et al. Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis.