Methyltransferase N6AMT1 (N6AMT1)

Methyltransferase that could methylate both proteins and DNA, and to a lesser degree, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity).

Methylates ETF1 on'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be economically methylated (PubMed:18539146, PubMed:20606008). Also functions as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) (PubMed:30017583).