Cytoplasmic protein NCK1 (NCK1)

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1.

Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for effective activation of downstream effectors, like that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.