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- Table of Contents
Facts about NADPH-dependent diflavin oxidoreductase 1.
Section of an electron transport chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.
Human | |
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Gene Name: | NDOR1 |
Uniprot: | Q9UHB4 |
Entrez: | 27158 |
Belongs to: |
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NADPH-dependent diflavin oxidoreductase NDOR1 family |
bA350O14.9; EC 1.6; MGC138148; NADPH dependent diflavin oxidoreductase 1; NADPH-dependent diflavin oxidoreductase 1; NADPH-dependent FMN and FAD containing oxidoreductase; NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1; NR1NADPH dependent FMN and FAD containing oxidoreductase
Mass (kDA):
66.763 kDA
Human | |
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Location: | 9q34.3 |
Sequence: | 9; NC_000009.12 (137205667..137219361) |
Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.
Cytoplasm, perinuclear region. Concentrated in perinuclear structure.
PMID: 10625700 by Paine M.J., et al. Cloning and characterization of a novel human dual flavin reductase.
PMID: 12871939 by Kwasnicka D.A., et al. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.