NEFL Antibodies

AND NEFL ELISA kits, NEFL Proteins

Many biological assays use antibodies to detect NEFL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEFL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEFL antibodies...

We validate the specificity of these antibodies to NEFL by testing them on tissues known to express NEFL positively and negatively. Browse below to find the NEFL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for NEFL? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the NEFL Western Blot Guide

NEFL Infographic by Boster Bio

All NEFL Products

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Specificity

Applications

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Anti-NEFL/NF-L Antibody Picoband®

1 Citations

IHC analysis of NEFL/NF-L using anti-NEFL/NF-L antibody (A02482-1)

Flow Cytometry analysis of 293T cells using anti-NEFL/NF-L antibody (A02482-1)

Western blot analysis of NEFL/NF-L using anti-NEFL/NF-L antibody (A02482-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A02482-1
100 μg/vial

Neurofilament (NEFL) (NM_006158) Human Over-expression Lysate

Human

$628
Cat # LS004747
20 µg, 100 µg

NEFL Overview

Facts about Neurofilament light polypeptide.

NEFL 3D structure. Source: alphafold

Neurofilament light polypeptide (NEFL)

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. .

Gene Information

Human
Gene Name:	NEFL
Uniprot:	P07196
Entrez:	4747

Family

Belongs to:

intermediate filament family

Alternative Names

68 kDa neurofilament protein; CMT2E; NEFL; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide; neurofilament-light; NF68; NF68FLJ53642; NFL; NF-L; NFLlight polypeptide 68kDa

Molecular Weight

Mass (kDA):
61.517 kDA

Genomic Context


Human

Location:	8p21.2
Sequence:	8; NC_000008.11 (24950955..24956612, complement)

Diseases

Charcot-marie-tooth Disease
Neoplasms
Malignant Neoplasms
Carcinoma
Prostatic Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Breast
Weakness
Demyelinating Diseases
Neoplasm Metastasis
Charcot-marie-tooth Disease, Axonal, Type 2e (disorder)

Carcinogenesis
Atrophy
Nervousness
Inherited Neuropathy
Peripheral Neuropathy
Muscle Weakness

Interacting Proteins

APP
CCDC172
DES
GFAP
GOLGA2

GORASP1
KRT13
KRT15
KRT18
MTMR2

NEFM
PPP1R18
SKIL
TERF1
VIM

Pathways

Pathogenesis
Transport
Localization
Dna Repair
Methylation
Cell Adhesion
Proteolysis
Dna Demethylation
Dna Methylation
Metaphase
Neuron Death
Myelination
Demethylation

Regeneration
Myelin Maintenance
Cell Motility
Cellular Localization
Cell Death
S Phase
Cell Growth

PTMs

Phosphorylation

Cleavage

Methylation

Research Areas

Cell Biology
Cellular Markers
Neurodegeneration
Neuronal Cell Markers
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEFL

References

PMID: 3034332 by Julien J.-P., et al. The structure of a human neurofilament gene (NF-L): a unique exon- intron organization in the intermediate filament gene family.

PMID: 12432080 by Perez-Olle R., et al. Effects of Charcot-Marie-Tooth-linked mutations of the neurofilament light subunit on intermediate filament formation.