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- Table of Contents
NME4 Antibodies
AND NME4 ELISA kits, NME4 Proteins
Many biological assays use antibodies to detect NME4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NME4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NME4 antibodies...
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NME4 Infographic by Boster Bio
All NME4 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M06126
100 µl
Cat # M06126
100 µl
NME4 Overview
Facts about Nucleoside diphosphate kinase, mitochondrial.
Nucleoside diphosphate kinase, mitochondrial (NME4)
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Through the catalyzed exchange of gamma- phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663).
Gene Information
| Human | |
|---|---|
| Gene Name: | NME4 |
| Uniprot: | O00746 |
| Entrez: | 4833 |
Family
| Belongs to: |
|---|
| NDK family |
Alternative Names
EC 2.7.4.6; NDP kinase, mitochondrial; NDPK-D; NM23D; nm23-H4mitochondrial; non-metastatic cells 4, protein expressed in
Molecular Weight
Mass (kDA):
20.659 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (396729..400754) |
Tissue Specificity
Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.
Subcellular Localizations
Mitochondrion intermembrane space; Peripheral membrane protein. Mitochondrion matrix. Predominantly localized in the mitochondrion intermembrane space (PubMed:18635542). Colocalizes with OPA1 in mitochondria (PubMed:24970086).
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Stomach Neoplasms
- Tumor Progression
- Colorectal Cancer
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Stomach
- Colorectal Neoplasms
- Embryonal Carcinoma
- Colonic Neoplasms
Interacting Proteins
- HTT
- NME1
- NME2
- TRIP13
Pathways
- Oxidative Phosphorylation
- Cell Adhesion
- Regeneration
- Reverse Transcription
- Cell Migration
- Rna Interference
- Localization
PTMs
- Phosphorylation
Research Areas
- Core ESC-Like Genes
- Lipid and Metabolism
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NME4
bosterbio.com/bosterbio-gene-info-cards/NME4
References
PMID: 9099850 by Milon L., et al. nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13.
PMID: 17028143 by Epand R.F., et al. Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes.