Protein NPAT Antibodies

AND NPAT ELISA kits, Protein NPAT Proteins

Many biological assays use antibodies to detect Protein NPAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein NPAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein NPAT antibodies...

We validate the specificity of these antibodies to Protein NPAT by testing them on tissues known to express NPAT positively and negatively. Browse below to find the NPAT antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPAT Infographic by Boster Bio

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NPAT Overview

Facts about Protein NPAT.

NPAT 3D structure. Source: alphafold

Protein NPAT (NPAT)

Required for progression through the G1 and S phases of the cell cycle and for S phase entry.
Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF.

Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.

Gene Information

Human
Gene Name:	NPAT
Uniprot:	Q14207
Entrez:	4863

Family

Belongs to:

NPAT family

Alternative Names

CAND3; E14; E14/NPAT; Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus; Nuclear Protein Of The ATM Locus; Nuclear Protein, Ataxia-Telangiectasia Locus; Nuclear Protein, Coactivator Of Histone Transcription; Nuclear Protein, Co-Activator Of Histone Transcription; p220; Protein NPAT

Molecular Weight

Mass (kDA):
154.29 kDA

Genomic Context


Human

Location:	11q22.3
Sequence:	11; NC_000011.10 (108155280..108222638, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus. Nucleus, Cajal body. Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.

Diseases

Malignant Neoplasms
Ataxia Telangiectasia
Neoplasms
Ataxia
Retinoblastoma
Telangiectasis
Malignant Neoplasm Of Breast
Lymphoma
Cell Transformation, Neoplastic
Aneuploidy
Malignant Tumor Of Cervix
Immunologic Deficiency Syndromes

Idiopathic Hypereosinophilic Syndrome
Hodgkin Disease
Leukemia
Hyperplasia
Radiation Injury
Sarcoma
Carcinoma

Pathways

Cell Cycle
S Phase
Dna Replication
Localization
Cell Proliferation
G1 Phase
Mitosis
Methylation
Rna Interference
Cell Cycle Phase
Cell Cycle Arrest
Cell Division
Histone H4 Acetylation

Histone Acetylation
Dna Methylation
Pathogenesis
Transport
Myoblast Proliferation
Cell Cycle Checkpoint
Gallstone Formation

PTMs

Phosphorylation
Acetylation

Methylation
Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPAT

References

PMID: 8743993 by Imai T., et al. Identification and characterization of a new gene physically linked to the ATM gene.

PMID: 8923007 by Byrd P.J., et al. A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies.