NPRL3 Antibodies

AND NPRL3 ELISA kits, NPRL3 Proteins

Many biological assays use antibodies to detect NPRL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPRL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPRL3 antibodies...

We validate the specificity of these antibodies to NPRL3 by testing them on tissues known to express NPRL3 positively and negatively. Browse below to find the NPRL3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPRL3 Infographic by Boster Bio

All NPRL3 Products

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NPRL3 (NM_001039476) Human Recombinant Protein

Coomassie blue staining of purified NPRL3 protein

$1249
Cat # PROTQ12980
20 µg

NPRL3 (NM_001039476) Human Over-expression Lysate

NPRL3 Human Over-expression Lysates NM_001039476

Human

$628
Cat # LS008131
20 µg, 100 µg

NPRL3 Overview

Facts about GATOR complex protein NPRL3.

NPRL3 3D structure. Source: alphafold

GATOR complex protein NPRL3 (NPRL3)

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing division of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

The GATOR1 complex is negatively controlled by GATOR2 the other GATOR subcomplex within this amino acid-sensing division of the TORC1 pathway. .

Gene Information

Human
Gene Name:	NPRL3
Uniprot:	Q12980
Entrez:	8131

Family

Belongs to:

NPR3 family

Alternative Names

-14 gene protein; Alpha-globin regulatory element-containing gene protein; C16orf35; CGTHBAchromosome 16 open reading frame 35; conserved gene telomeric to alpha globin cluster; MAREHS-40; nitrogen permease regulator 3-like protein; nitrogen permease regulator-like 3 (S. cerevisiae); NPR3; Protein CGTHBA; RMD11

Molecular Weight

Mass (kDA):
63.605 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (85386..138698, complement)

Tissue Specificity

Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888).

Subcellular Localizations

Lysosome membrane. Localization to lysosomes is amino acid-independent.

Diseases

Congenital Heart Defects

Interacting Proteins

NPRL2
SZT2

Pathways

Cell Cycle
Cell Growth

PTMs

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPRL3

References

PMID: 8575760 by Vyas P., et al. Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.

PMID: 16728641 by De Gobbi M., et al. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.