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1 Citations 6 Q&As
1 Citations
Facts about Mineralocorticoid receptor.
The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. .
Human | |
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Gene Name: | NR3C2 |
Uniprot: | P08235 |
Entrez: | 4306 |
Belongs to: |
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nuclear hormone receptor family |
FLJ41052; MGC133092; Mineralocorticoid R; mineralocorticoid receptor 1; mineralocorticoid receptor delta; MineralocorticoidR; MLR; MLRmineralocorticoid receptor; MRMCRaldosterone receptor; NR3C2; NR3C2VIT; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2
Mass (kDA):
107.082 kDA
Human | |
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Location: | 4q31.23 |
Sequence: | 4; NC_000004.12 (148078764..148444698, complement) |
Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
This article will aid you in making an informed choice if you are in search of an NR3C2 marker to use in research or clinical research. This article contains details about Eplerenone and Rabbit polyclonal MR antibodies, Mouse monoclonal p53 antibodies as well as a variety of other products from Boster. Continue reading to learn more about these products as well as their best uses.
The Anti-Mineralocorticoid Receptor/NR3C2 antibody from Boster Bio reacts with Human, Mouse, and Rat proteins. This product can be used to investigate inflammatory bowel diseases, tumors and liver disease. For optimal performance you must conduct multiple reactions to ensure that the antibody is specific and has high affinity.
NR3C2 is a gene coding for the protein nitroreductase. It is involved in the regulation of blood pressure levels. Eplerenone is produced by Wuhan Boster Biological Technology, Ltd. in China. It is also available from MedChemExpress. This medication is not recommended to pregnant women or mothers who are nursing. Because small amounts of eplerenone might enter the breast milk breastfeeding is recommended. Eplerenone is generally safe for both mother and baby. However, mothers who are breastfeeding should be aware of their blood pressure.
Eplerenone is taken orally as a tablet. It is typically taken once or twice daily, at the same time every day. The dosage may be upped to 50mg once a day and can be reduced or completely stopped. A physician will recommend the dosage and it should be adhered to. Depending on the levels of potassium in your body, the dosage could be reduced temporarily.
The side effects of eplerenone can include diarrhoea and muscle cramps. It can also cause sleepiness and weakness. It can cause blurred vision or eyesight. It could also increase potassium levels. Although eplerenone may be consumed by the majority of adults over 18, it can have side effects.
The aging-induced upregulation of the gp91-phox and p47-phox in cardiomyocyte by H2O2 therapy caused a marked imbalance in redox state. Eplerenone reduced the aging-induced damage to cardiomyocytes. It also raised levels of SOD-1 and SOD-2.
The NR3C2 marker is located on the surface of the hippocampus. This marker is located inside the hippocampus. It is involved in regulating gene expression. This antibody has a distinct affinity for the hippocampus and is strongly associated with the gene rbx1. This antibody is strongly associated with genes that are involved in memory, learning, anxiety. It is a hippocampus-specific antibody that regulates a variety of processes related to memory, learning and neuroplasticity. It has been found to play a major role in mediating the effects of GCs.
This antibody was generated against the C-terminus in human NR3C2. It is specifically targeted to members of the NR3C2 superfamily. The researcher must determine the most effective concentration of this antibody. The ideal temperature for storage of the antibody is 4oC, while long-term storage should be at -20oC. The antibody is made by immunizing rabbits using synthetic peptides found at the C-terminus on human NR3C2. The antibody is not intended for human consumption.
NR3C2 is an antigen that is highly specific, allowing this antibody to recognize a variety of proteins within the cilium. The cilium, which is the largest part of the cilium, is responsible for the creation of many kinds of cells, including the cilia. This antigen is also extremely reactive to dysneins from the axonemal system.
The NR3C2 marker is found on a variety of proteins including Adiponectin. The NR3C2 marker is utilized to target the NR3C2 mark in cells in culture. It can be useful in studying the interaction between proteins MR and GR. It can be used for purification of proteins and ELISA analysis. The results are shown in a Venn diagram.
Although the NR3C2 marker can be found on the surface neuronal cells However, its absence may not be enough to differentiate neuronal tissue. This antibody also blocks the NR3C2 transcript. Besides blocking NR3C2 signaling, it also blocks the differentiation of neurons. These findings also suggest the existence of various pathways within the brain.
This boster bio mouse monoclonal antibody p53 reacts with Human p53. The monoclonal antibody is provided in PBS containing 0.09 percent sodium azide. The boster bio antip53 antibody was isolated by using a protein-G column as well as dialysis using PBS. This antibody is produced by immunizing mice using a synthetic peptide that contains between 1 and 393 amino acids derived from human p53. Alternately, you can purchase blocking peptides and use them for an anti-inflammatory.
Boster Bio anti-p53 antibodies recognize p53 (acetyl K370) which is a cell-specific antigen. They have been validated for Western Blot, Immunocytochemistry, and ICC assays. The antibodies are available as 100 ul in Liquid form. The Boster mouse monoclonal antibody p53 antibody is a reliable and flexible tool for your research.
Mutations in TP53 have been linked to various forms of cancer, including kidney and respiratory tract cancer. However, G/C to A/T transitions are more common in colorectal and brain cancers. Environmental mutagens , like tobacco smoke, are thought to alter p53 levels by forming DNA adducts as well as altering codons. These mutations could be caused by AFB1, however nobody knows for certain.
PMID: 3037703 by Arriza J.L., et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.
PMID: 11518808 by Zennaro M.-C., et al. A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.
*More publications can be found for each product on its corresponding product page