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NTHL1 Antibodies
AND NTHL1 ELISA kits, NTHL1 Proteins
Many biological assays use antibodies to detect NTHL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NTHL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NTHL1 antibodies...
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NTHL1 Infographic by Boster Bio
All NTHL1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03207-2
100 µg/vial
Cat # A03207-2
100 µg/vial
NTHL1 Overview
Facts about Endonuclease III-like protein 1.
Endonuclease III-like protein 1 (NTHL1)
Bifunctional DNA N-glycosylase with related apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase action releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP website.
Primarily recognizes and fixes oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | NTHL1 |
| Uniprot: | P78549 |
| Entrez: | 4913 |
Family
| Belongs to: |
|---|
| Nth/MutY family |
Alternative Names
EC 4.2.99.18; endonuclease III-like protein 1; nth endonuclease III-like 1 (E. coli); NTH1; NTHL1; OCTS3; OCTS3NTH1nth (E.coli endonuclease III)-like 1
Molecular Weight
Mass (kDA):
34.39 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (2039820..2047834, complement) |
Tissue Specificity
Widely expressed with highest levels in heart and lowest levels in lung and liver.
Subcellular Localizations
Nucleus. Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Sclerosis
- Carcinogenesis
- Tuberous Sclerosis
- Carcinoma
- Colorectal Cancer
- Adenoma
- Adenocarcinoma
- Colorectal Neoplasms
- Dna Injury
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Ovary
Pathways
- Dna Repair
- Pathogenesis
- Localization
- Cell Adhesion
- Cell Proliferation
- Cell Killing
- Aging
- Proteolysis
- Virulence
- Drug Resistance
- Dna Replication
PTMs
- Oxidation
Research Areas
- Base Excision Repair
- Cancer
- Chromatin Research
- Core ESC-Like Genes
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTHL1
bosterbio.com/bosterbio-gene-info-cards/NTHL1
References
PMID: 8990169 by Aspinwall R., et al. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III.
PMID: 9831664 by Imai K., et al. Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.