NEDD8 ultimate buster 1 Antibodies

AND NUB1 ELISA kits, NEDD8 ultimate buster 1 Proteins

Many biological assays use antibodies to detect NEDD8 ultimate buster 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEDD8 ultimate buster 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEDD8 ultimate buster 1 antibodies...

We validate the specificity of these antibodies to NEDD8 ultimate buster 1 by testing them on tissues known to express NUB1 positively and negatively. Browse below to find the NUB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for NEDD8 ultimate buster 1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the NUB1 IHC Guide

NUB1 Infographic by Boster Bio

All NUB1 Products

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Applications

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Anti-NUB1 Antibody Picoband®

Western blot analysis of NUB1 using anti-NUB1 antibody (A06089-2)

IHC analysis of NUB1 using anti-NUB1 antibody (A06089-2)

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06089-2
100 µg/vial

NYREN18 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from COS7 cells

Human, Mouse

ELISA

$480
Cat # EKC1412
1 kit, containing one 96-well plate and all necessary reagents

NYREN18 (NUB1) (NM_016118) Human Over-expression Lysate

Human

$628
Cat # LS051667
20 µg, 100 µg

NUB1 Overview

Facts about NEDD8 ultimate buster 1.

NUB1 3D structure. Source: alphafold

NEDD8 ultimate buster 1 (NUB1)

Particular down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates into the proteasome for degradation.

Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. .

Gene Information

Human
Gene Name:	NUB1
Uniprot:	Q9Y5A7
Entrez:	51667

Family

Belongs to:

No superfamily

Alternative Names

BS4; NEDD8 ultimate buster-1; negative regulator of ubiquitin-like proteins 1NUB1L; NUB1; NUB1L; NY-REN-18 antigen; NY-REN-18; NYREN18NEDD8 ultimate buster 1; Renal carcinoma antigen NY-REN-18

Molecular Weight

Mass (kDA):
70.538 kDA

Genomic Context


Human

Location:	7q36.1
Sequence:	7; NC_000007.14 (151341699..151378461)

Tissue Specificity

Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.

Subcellular Localizations

Nucleus. Predominantly nuclear.

Diseases

Amaurosis
Leber Congenital Amaurosis
Blind Vision
Optic Atrophy, Hereditary, Leber
Neurodegenerative Disorders
Parkinson Disease
Malignant Neoplasms
Retinal Degeneration
Dementia
Lewy Body Disease
Lymphoma
Acute Interstitial Pneumonia

Retinoblastoma
Alzheimer's Disease
Pick Disease Of The Brain
Von Hippel-lindau Syndrome
Pre-eclampsia
Kidney Neoplasm
Progressive Supranuclear Palsy

Interacting Proteins

AIPL1
SF3B4
TERF1

Pathways

Conjugation
Localization
Cell Cycle
Cell Growth
Pathogenesis
Proteolysis
Autophagy
Transport
Hyperphosphorylation
Regulation Of Cell Cycle
Cell Proliferation

Protein Maturation
Endocytosis
Spermatogenesis
Regulation Of Cell Growth
Rna Interference
Meiosis

PTMs

Ubiquitination
Phosphorylation

Reduction
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUB1

References

PMID: 11259415 by Kito K., et al. NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression.

PMID: 12816948 by Tanaka T., et al. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.