Baculoviral IAP repeat-containing protein 1b (Naip2)

Sensor component of this NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins like S.typhimurium (Salmonella) PrgJ and B.

thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis.