2'-5'-oligoadenylate synthase-like protein 2 (Oasl2)

Interferon-induced, dsRNA-activated antiviral receptor that plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) resulting in its dimerization and subsequent activation.

Activation of RNase L contributes to degradation of cellular in addition to viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect through the classical RNase L-dependent pathway or another antiviral pathway independent of RNase L.