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- Table of Contents
OGDH Antibodies
AND OGDH ELISA kits, OGDH Proteins
Many biological assays use antibodies to detect OGDH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OGDH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OGDH antibodies...
Designing a Western blot for OGDH? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OGDH Western Blot GuideOGDH Infographic by Boster Bio
All OGDH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A10713-1
100 µg/vial
Cat # A10713-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05301-1
100 µg/vial
Cat # A05301-1
100 µg/vial
OGDH Overview
Facts about 2-oxoglutarate dehydrogenase, mitochondrial.
2-oxoglutarate dehydrogenase, mitochondrial (OGDH)
2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:24495017).
The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is necessary for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).
Gene Information
| Human | |
|---|---|
| Gene Name: | OGDH |
| Uniprot: | Q02218 |
| Entrez: | 4967 |
Family
| Belongs to: |
|---|
| alpha-ketoglutarate dehydrogenase family |
Alternative Names
2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase, mitochondrial; AKGDH; alpha KGD; alpha-KGD; E1k; OGDC; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate decarboxylase; oxoglutarate dehydrogenase (succinyl-transferring)
Molecular Weight
Mass (kDA):
115.935 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p13 |
| Sequence: | 7; NC_000007.14 (44606572..44709066) |
Subcellular Localizations
Mitochondrion matrix. Nucleus. Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Diseases
- Diabetes Mellitus
- Malignant Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Overnutrition
- Coronary Heart Disease
- Insulinoma
- Infarction
- Malignant Neoplasm Of Breast
- Hepatic Encephalopathy
- Hypoxia
- Hyperammonemia
- Coronary Artery Disease
- Malignant Tumor Of Cervix
Pathways
- Oxidative Phosphorylation
- Localization
- Secretion
- Transport
- Pyruvate Oxidation
- Cell Proliferation
- Skeletal Muscle Adaptation
- Tricarboxylic Acid Cycle
- Membrane Hyperpolarization
- Insulin Secretion
- Platelet Activation
PTMs
- Decarboxylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OGDH
bosterbio.com/bosterbio-gene-info-cards/OGDH
References
PMID: 1542694 by Koike K., et al. Cloning and nucleotide sequence of the cDNA encoding human 2- oxoglutarate dehydrogenase (lipoamide).
PMID: 7622061 by Koike K.; The gene encoding human 2-oxoglutarate dehydrogenase: structural organization and mapping to chromosome 7p13-p14.