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- Table of Contents
PARG Antibodies
AND PARG ELISA kits, PARG Proteins
Many biological assays use antibodies to detect PARG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARG antibodies...
Designing a Western blot for PARG? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PARG Western Blot GuidePARG Infographic by Boster Bio
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PARG Overview
Facts about Poly(ADP-ribose) glycohydrolase.
Poly(ADP-ribose) glycohydrolase (PARG)
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is quickly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699).
Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression in RAR- dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257).
Gene Information
| Human | |
|---|---|
| Gene Name: | PARG |
| Uniprot: | Q86W56 |
| Entrez: | 8505 |
Family
| Belongs to: |
|---|
| poly(ADP-ribose) glycohydrolase family |
Alternative Names
EC 3.2.1.143; FLJ54459; FLJ60257; FLJ60456; PARG; PARG99; poly (ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform; poly(ADP-ribose) glycohydrolase
Molecular Weight
Mass (kDA):
111.11 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q11.23 |
| Sequence: | 10; NC_000010.11 (49818274..49942027, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
[Isoform 1]: Nucleus. Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818).; [Isoform 2]: Cytoplasm. Translocates to the nucleus in response to DNA damage.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm. Mitochondrion.; [Isoform 5]: Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Genotoxic Stress
- Ischemia
- Carcinoma
- Genomic Instability
- Carcinogenesis
- Infarction
- Tissue Adhesions
- Brain Ischemia
- Reperfusion Injury
Pathways
- Cell Death
- Dna Repair
- Localization
- Cell Division
- Cell Differentiation
- Mitosis
- Rna Interference
- Dna Replication
- Inflammatory Response
- Cell Cycle
- Necrotic Cell Death
- Cell Growth
- Chromatin Remodeling
PTMs
- Cleavage
- Phosphorylation
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARG
bosterbio.com/bosterbio-gene-info-cards/PARG
References
PMID: 14527731 by Meyer R.G., et al. Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23).
PMID: 15212953 by Meyer-Ficca M.L., et al. Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.