Paired box protein Pax-4 Antibodies

AND PAX4 ELISA kits, Paired box protein Pax-4 Proteins

Many biological assays use antibodies to detect Paired box protein Pax-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Paired box protein Pax-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Paired box protein Pax-4 antibodies...

We validate the specificity of these antibodies to Paired box protein Pax-4 by testing them on tissues known to express PAX4 positively and negatively. Browse below to find the PAX4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Paired box protein Pax-4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PAX4 Western Blot Guide

PAX4 Infographic by Boster Bio

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Anti-PAX4 Antibody Picoband®

Western blot analysis of PAX4 using anti-PAX4 antibody (A03165-2)

Flow Cytometry analysis of A431 cells using anti-PAX4 antibody (A03165-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03165-2
100 μg/vial

PAX4 Overview

Facts about Paired box protein Pax-4.

PAX4 3D structure. Source: alphafold

Paired box protein Pax-4 (PAX4)

Plays an essential role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a frequent element in the glucagon, insulin and somatostatin promoters.

Competes with PAX6 with this same promoter binding site. Isoform 2 seems to be a dominant negative form antagonizing PAX4 transcriptional activity.

Gene Information

Human
Gene Name:	PAX4
Uniprot:	O43316
Entrez:	5078

Family

Belongs to:

paired homeobox family

Alternative Names

KPD; MGC129960; MODY9paired box protein Pax-4; paired box 4; paired box gene 4; paired domain gene 4; Pax4

Molecular Weight

Mass (kDA):
37.833 kDA

Genomic Context


Human

Location:	7q32.1
Sequence:	7; NC_000007.14 (127610292..127618142, complement)

Subcellular Localizations

Nucleus.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Diabetes Mellitus, Non-insulin-dependent
Hyperglycemia
Insulinoma
Diabetes Mellitus, Experimental
Neoplasms
Pancreatic Neoplasm
Insulin Resistance
Autoimmunity
Malignant Neoplasms
Cell Transformation, Neoplastic
Impaired Glucose Tolerance

Severe Combined Immunodeficiency
Dysequilibrium Syndrome
Glucagonoma
Hyperinsulinism
Hyperplasia
Carcinoma
Hypoglycemia

Pathways

Pancreas Development
Cell Differentiation
Secretion
Insulin Secretion
Cell Development
Regeneration
Transdifferentiation
Cell Growth
Cell Proliferation
Pathogenesis
Glucose Homeostasis
Endocrine Pancreas Development
Cell Cycle

Reverse Transcription
Methylation
Developmental Process
Dna Methylation
Notch Signaling Pathway
Transport
Cell Cycle Arrest

PTMs

Methylation
Demethylation

Phosphorylation
Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAX4

References

PMID: 9439631 by Matsushita T., et al. Molecular cloning of mouse paired-box-containing gene (Pax-4) from an islet beta cell line and deduced sequence of human Pax-4.

PMID: 9753306 by Tao T., et al. Isolation and characterization of the human PAX4 gene.