PDE11A Antibodies

AND PDE11A ELISA kits, PDE11A Proteins

Many biological assays use antibodies to detect PDE11A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE11A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE11A antibodies...

We validate the specificity of these antibodies to PDE11A by testing them on tissues known to express PDE11A positively and negatively. Browse below to find the PDE11A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE11A Infographic by Boster Bio

All PDE11A Products

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Applications

Price

PDE11A (NM_016953) Human Over-expression Lysate

Human

$960
Cat # LS050940
100 µg

PDE11A Overview

Facts about Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A.

PDE11A 3D structure. Source: alphafold

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively.

Gene Information

Human
Gene Name:	PDE11A
Uniprot:	Q9HCR9
Entrez:	50940

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; cyclic nucleotide phosphodiesterase 11A; dual 3'-5'-cyclic-AMP and -GMP phosphodiesterase 11A; EC 3.1.4; EC 3.1.4.17; EC 3.1.4.35; FLJ23693; MGC133355; MGC133356; PDE11A1; PDE11A2; PDE11A3; phosphodiesterase 11A; PPNAD2

Molecular Weight

Mass (kDA):
104.752 kDA

Genomic Context


Human

Location:	2q31.2
Sequence:	2; NC_000002.12 (177623244..178108339, complement)

Tissue Specificity

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.

Subcellular Localizations

Cytoplasm, cytosol.

Diseases

Neoplasms
Hyperplasia
Cushing Syndrome
Adenoma
Tumors Of Adrenal Cortex
Carney Complex
Adrenal Hyperplasia
Malignant Neoplasms
Adrenal Cortex Diseases
Depressive Disorder
Adrenal Cortical Hyperplasia
Carcinoma
Adrenal Cortical Adenoma

Cell Transformation, Neoplastic
Testicular Neoplasms
Pituitary Diseases
Major Depressive Disorder
Testicular Germ Cell Tumor
Pigmentation Disorders
Multiple Endocrine Neoplasia

Pathways

Secretion
Pathogenesis
Pigmentation
Cortisol Secretion
Localization
Cellular Response To Dsrna
Transport
Protein Phosphorylation
Fertilization
Spermatogenesis
Cell Cycle
Cell Differentiation
Dsrna Fragmentation

Catabolic Process
Hormone Secretion
Transmembrane Transport
Insulin Secretion
Response To Dsrna
Methylation
Erbb Signaling Pathway

PTMs

Phosphorylation

Methylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE11A

References

PMID: 10906126 by Yuasa K., et al. Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression.

PMID: 10725373 by Fawcett L., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.