PDE1C Antibodies

AND PDE1C ELISA kits, PDE1C Proteins

Many biological assays use antibodies to detect PDE1C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE1C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE1C antibodies...

We validate the specificity of these antibodies to PDE1C by testing them on tissues known to express PDE1C positively and negatively. Browse below to find the PDE1C antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE1C Infographic by Boster Bio

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PDE1C Overview

Facts about Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C.

PDE1C 3D structure. Source: alphafold

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C)

Cyclic nucleotide phosphodiesterase using a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Gene Information

Human
Gene Name:	PDE1C
Uniprot:	Q14123
Entrez:	5137

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

calmodulin-dependent (70kD); EC 3.1.4; phosphodiesterase 1C, calmodulin-dependent 70kDa

Molecular Weight

Mass (kDA):
80.76 kDA

Genomic Context


Human

Location:	7p14.3
Sequence:	7; NC_000007.14 (31616777..32428224, complement)

Tissue Specificity

Expressed in several tissues, including brain and heart.

Diseases

Hypertensive Disease
Pulmonary Hypertension
Erectile Dysfunction
Cardiac Hypertrophy
Malignant Paraganglionic Neoplasm
Hypertrophy
Idiopathic Pulmonary Hypertension
Atherosclerosis
Carcinoma
Heart Failure
Insulinoma
Osteosarcoma

Vascular Diseases
Malignant Neoplasm Of Thyroid
Right Ventricular Hypertrophy
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 (disorder)
Melanoma
Sudden Infant Death Syndrome
Hypoxia

Pathways

Localization
Cell Proliferation
Insulin Secretion
Secretion
Smooth Muscle Cell Proliferation
Muscle Cell Proliferation
Cognition
Protein Phosphorylation
Cell Adhesion
Vasodilation
Sensory Processing
Camp-mediated Signaling
Penile Erection

Copulation
Male Mating Behavior
Axon Extension
Reverse Transcription
Cell Cycle
Cellular Localization
Prophase

PTMs

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE1C

References

PMID: 8557689 by Loughney K., et al. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.

PMID: 29860631 by Wang L., et al. A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.