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PDE4B Antibodies
AND PDE4B ELISA kits, PDE4B Proteins
Many biological assays use antibodies to detect PDE4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE4B antibodies...
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PDE4B Infographic by Boster Bio
All PDE4B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A02228S133
100ul
Cat # A02228S133
100ul
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02228
100 µl
Cat # M02228
100 µl
PDE4B Overview
Facts about cAMP-specific 3',5'-cyclic phosphodiesterase 4B.
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B)
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents which range from antidepressants to antiasthmatic and anti inflammatory agents.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE4B |
| Uniprot: | Q07343 |
| Entrez: | 5142 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
cAMP-specific (phosphodiesterase E4 dunce homolog; cAMP-specific 3'-5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; DKFZp686F2182; Drosophila); dunce-like phosphodiesterase E4; EC 3.1.4; EC 3.1.4.17; MGC126529; PDE32; PDEIVB; phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E4); phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific; phosphodiesterase E4 dunce homolog
Molecular Weight
Mass (kDA):
83.343 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.3 |
| Sequence: | 1; NC_000001.11 (65792510..66374579) |
Tissue Specificity
Expressed in brain, heart, lung and skeletal muscle.
Diseases
- Schizophrenia
- Inflammation
- Depressive Disorder
- Mental Disorders
- Malignant Neoplasms
- Asthma
- Bipolar Disorder
- Vomiting
- Neoplasms
- Chronic Obstructive Airway Disease
- Tissue Adhesions
- Lung Diseases
- Lymphoma
Pathways
- Pathogenesis
- Secretion
- Localization
- Cell Proliferation
- Immune Response
- Chemotaxis
- Cell Cycle
- Cytokine Production
- Cell Adhesion
- Cell Activation
- Cell Migration
- Regeneration
- Inflammatory Response
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Cancer
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE4B
bosterbio.com/bosterbio-gene-info-cards/PDE4B
References
PMID: 8392015 by Obernolte R., et al. The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
PMID: 8413254 by Bolger G., et al. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.