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- Table of Contents
PDE5A Antibodies
AND PDE5A ELISA kits, PDE5A Proteins
Many biological assays use antibodies to detect PDE5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE5A antibodies...
Designing a Western blot for PDE5A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDE5A Western Blot GuidePDE5A Infographic by Boster Bio
All PDE5A Products
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Specificity
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PDE5A Overview
Facts about cGMP-specific 3',5'-cyclic phosphodiesterase.
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). .
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE5A |
| Uniprot: | O76074 |
| Entrez: | 8654 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
CGB-PDE; cGMP-binding cGMP-specific 3'-5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3'-5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase type 5A; CN5A; EC 3.1.4; EC 3.1.4.35; PDE5; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5
Molecular Weight
Mass (kDA):
99.985 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q26 |
| Sequence: | 4; NC_000004.12 (119494395..119628804, complement) |
Tissue Specificity
Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Diseases
- Erectile Dysfunction
- Hypertensive Disease
- Pulmonary Hypertension
- Cardiovascular Diseases
- Heart Failure
- Diabetes Mellitus
- Headache
- Observation Of Neuromuscular Block
- Idiopathic Pulmonary Hypertension
- Hypertrophy
- Dyspepsia
- Ischemia
Interacting Proteins
- PRKG1
Pathways
- Vasodilation
- Penile Erection
- Localization
- Cell Proliferation
- Vasoconstriction
- Pathogenesis
- Platelet Aggregation
- Aging
- Excretion
- Angiogenesis
- Secretion
- Neurogenesis
- Cell Growth
PTMs
- Phosphorylation
- Nitration
- Carboxylation
Research Areas
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE5A
bosterbio.com/bosterbio-gene-info-cards/PDE5A
References
PMID: 9714779 by Loughney K., et al. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
PMID: 9716380 by Yanaka N., et al. Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene.
1 Publications of Boster PDE5A Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.acthis.2018.03.002, An immunohistochemical and ultrastructural analysis of the retina in tadalafil (...
*More publications can be found for each product on its corresponding product page