PDHX Antibodies

AND PDHX ELISA kits, PDHX Proteins

Many biological assays use antibodies to detect PDHX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDHX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDHX antibodies...

We validate the specificity of these antibodies to PDHX by testing them on tissues known to express PDHX positively and negatively. Browse below to find the PDHX antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDHX Infographic by Boster Bio

All PDHX Products

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Specificity

Applications

Price

Anti-PDHX Antibody

Western blot analysis of extracts of various cell lines, using PDHX antibody at 1:1000 dilution

Immunoprecipitation analysis of 600ug extracts of Mouse brain cells using 3ug PDHX antibody

Human, Mouse, Rat

IP, WB

$405
Cat # A04836
100ul

PDHX (NM_003477) Human Recombinant Protein

Coomassie blue staining of purified PDHX protein

$1249
Cat # PROTO00330
20 µg

PDHX (NM_003477) Human Over-expression Lysate

PDHX Human Over-expression Lysates NM_001135024

Human

$628
Cat # LS008050
20 µg, 100 µg

Anti-PDHX antibody

IHC analysis of PDHX using anti-PDHX antibody (A04836-2)

Human, Mouse, Rat

ELISA, IP, IHC, WB

$370
Cat # A04836-2
100 μl/vial

PDHX Overview

Facts about Pyruvate dehydrogenase protein X component, mitochondrial.

PDHX 3D structure. Source: alphafold

Pyruvate dehydrogenase protein X component, mitochondrial (PDHX)

Required for anchoring dihydrolipoamide dehydrogenase (E3) into the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This particular binding is essential for a functional PDH complex.

Gene Information

Human
Gene Name:	PDHX
Uniprot:	O00330
Entrez:	8050

Family

Belongs to:

2-oxoacid dehydrogenase family

Alternative Names

Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenasecomplex; DLDBP; E3-binding protein; E3BP; E3BP1; E3BPpyruvate dehydrogenase complex, E3-binding protein subunit; OPDX; PDHX; PDX1; PDX1Lipoyl-containing pyruvate dehydrogenase complex component X; proX; proXpyruvate dehydrogenase complex, lipoyl-containing component X; pyruvate dehydrogenase complex, component X; pyruvate dehydrogenase protein X component, mitochondrial

Molecular Weight

Mass (kDA):
54.122 kDA

Genomic Context


Human

Location:	11p13
Sequence:	11; NC_000011.10 (34915829..34996128)

Subcellular Localizations

Mitochondrion matrix.

Diseases

Biliary Cirrhosis
Primary Biliary Cirrhosis
Liver Cirrhosis
Pyruvate Dehydrogenase Complex Deficiency Disease
Autoimmune Reaction
Acidosis
Acidosis, Lactic
Autoimmune Diseases
Liver Diseases
Protein Deficiency
Leigh Disease
Encephalopathies
Autoimmunity

Ataxia
De Novo Mutation
Inflammation
Lactic Acidemia
Developmental Delay (disorder)
Acidemia
Chronic Liver Disease

Interacting Proteins

AGTRAP
DLD
SIRT4

Pathways

Pathogenesis
Immune Response
Transport
Cell Adhesion
Regeneration
Pyruvate Oxidation
Brain Development
Liver Regeneration

Cognition
Inflammatory Response

PTMs

Cleavage
Phosphorylation

Acetylation
Oxidation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDHX

References

PMID: 9242632 by Harris R.A., et al. Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex.

PMID: 9399911 by Aral B., et al. Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis.