PDZRN3 Antibodies

AND PDZRN3 ELISA kits, PDZRN3 Proteins

Many biological assays use antibodies to detect PDZRN3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDZRN3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDZRN3 antibodies...

We validate the specificity of these antibodies to PDZRN3 by testing them on tissues known to express PDZRN3 positively and negatively. Browse below to find the PDZRN3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDZRN3 Infographic by Boster Bio

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SEMCAP3 (PDZRN3) (NM_015009) Human Over-expression Lysate

Human

$960
Cat # LS023024
20 µg, 100 µg

PDZRN3 Overview

Facts about E3 ubiquitin-protein ligase PDZRN3.

PDZRN3 3D structure. Source: alphafold

E3 ubiquitin-protein ligase PDZRN3 (PDZRN3)

E3 ubiquitin-protein ligase. Plays an essential part in regulating the surface level of MUSK on myotubes.

Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.

Gene Information

Human
Gene Name:	PDZRN3
Uniprot:	Q9UPQ7
Entrez:	23024

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase PDZRN3; EC 6.3.2.-; Ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; LNX3KIAA1095SEMACAP3; PDZ domain containing ring finger 3; PDZ domain-containing RING finger protein 3; Protein SEMACAP3; Semaphorin cytoplasmic domain-associated protein 3; SEMCAP3

Molecular Weight

Mass (kDA):
119.596 kDA

Genomic Context


Human

Location:	3p13
Sequence:	3; NC_000003.12 (73382430..73624997, complement)

Tissue Specificity

Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.

Subcellular Localizations

Cell junction, synapse. Cytoplasm. Localizes to the postsynaptic region of neuromuscular junctions.

Diseases

Loss Of Chromosome 3
Clinodactyly
Muscular Fasciculation
Von Hippel-lindau Syndrome
Hereditary Pancreatic Carcinoma
Kidney Neoplasm
Carcinogenesis
Carcinoma
Congenital Anomaly Of Face
Malignant Neoplasms
Neoplasms
Nervousness

Renal Cell Carcinoma
Pancreatic Neoplasm
Malignant Neoplasm Of Pancreas
Cell Transformation, Neoplastic
Hereditary Diseases
Congenital Abnormality

Pathways

Osteoblast Differentiation
Cell Fate Determination
Rna Interference
Regeneration
Receptor Clustering
Neurogenesis
Endocytosis

Localization

PTMs

Phosphorylation

Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDZRN3

References

PMID: 15010864 by Katoh M., et al. Identification and characterization of PDZRN3 and PDZRN4 genes in silico.

PMID: 15305371 by Santin A.D., et al. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy.