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Proenkephalin-A Antibodies

AND PENK ELISA kits, Proenkephalin-A Proteins

Many biological assays use antibodies to detect Proenkephalin-A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proenkephalin-A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proenkephalin-A antibodies...

We validate the specificity of these antibodies to Proenkephalin-A by testing them on tissues known to express PENK positively and negatively. Browse below to find the PENK antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PENK Infographic by Boster Bio

PENK protein infographic

All PENK Products

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Anti-Proenkephalin-A PENK Antibody

WesternBlot (WB) analysis of PENK polyclonal antibody

WesternBlot (WB) analysis of PENK polyclonal antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A07495-1
100ul

Anti-PENK Antibody

2 Citations

Anti-PENK Antibody at 1:2000 dilution + HT-29 whole cell lysateLysates/proteins at 20 µg per lane

Anti-PENK Antibody at 1:2000 dilution + HT-29 whole cell lysateLysates/proteins at 20 µg per lane

Human

WB

$299
Cat # M07495
50 µl

PENK Overview

Facts about Proenkephalin-A.

PENK 3D structure

PENK 3D structure. Source: alphafold

Proenkephalin-A (PENK)

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a part in several of physiologic functions, including pain perception and responses to stress.

PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) reduces GABA concentration in the striatum.

Gene Information

Human
Gene Name:	PENK
Uniprot:	P01210
Entrez:	5179

Gene Information

Family

Belongs to:

opioid neuropeptide precursor family

Family

Alternative Names

enkephalin A; preproenkephalin; proenkephalin; proenkephalin-A

Molecular Weight

Mass (kDA):
30.787 kDA

Molecular Weight

Genomic Context


Human

Location:	8q12.1
Sequence:	8; NC_000008.11 (56440957..56446641, complement)

Subcellular Localizations

Secreted.

Subcellular Localization

Diseases

Pituitary Diseases
Pain
Disease Of Adrenal Medulla
Malignant Neoplasms
Parkinson Disease
Neoplasms
Substance-related Disorders
Nervousness
Convulsions
Catalepsy
Muscle Rigidity

Huntington Disease
Epilepsy
Mood Disorders
Globus Hystericus
Combat Disorders
Encephalitis

Disease

Interacting Proteins

OPRM1

Interacting Proteins

Pathways

Secretion
Methylation
Dna Methylation
Localization
Parturition
Synaptic Transmission
Aging
Neurogenesis
Reflex
Bone Development
Response To Stress
Lactation
Neuroprotection

Gonadotropin Secretion
Pathogenesis
Cell Activation
Dna Hypermethylation
Dna Hypomethylation
Osteoblast Differentiation
Immune Response

Pathways

PTMs

Methylation
Cleavage

Phosphorylation
Reduction

Research Areas

Neuroscience

Research Areas

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PENK

References

PMID: 7057924 by Comb M., et al. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.

PMID: 6281660 by Noda M., et al. Isolation and structural organization of the human preproenkephalin gene.