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- Table of Contents
Proenkephalin-A Antibodies
AND PENK ELISA kits, Proenkephalin-A Proteins
Many biological assays use antibodies to detect Proenkephalin-A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proenkephalin-A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proenkephalin-A antibodies...
Designing a Western blot for Proenkephalin-A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PENK Western Blot GuidePENK Infographic by Boster Bio
All PENK Products
Product
Figures
Specificity
Applications
Price
PENK Overview
Facts about Proenkephalin-A.
Proenkephalin-A (PENK)
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a part in several of physiologic functions, including pain perception and responses to stress.
PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) reduces GABA concentration in the striatum.
Gene Information
| Human | |
|---|---|
| Gene Name: | PENK |
| Uniprot: | P01210 |
| Entrez: | 5179 |
Family
| Belongs to: |
|---|
| opioid neuropeptide precursor family |
Alternative Names
enkephalin A; preproenkephalin; proenkephalin; proenkephalin-A
Molecular Weight
Mass (kDA):
30.787 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.1 |
| Sequence: | 8; NC_000008.11 (56440957..56446641, complement) |
Subcellular Localizations
Secreted.
Diseases
- Pituitary Diseases
- Pain
- Disease Of Adrenal Medulla
- Malignant Neoplasms
- Parkinson Disease
- Neoplasms
- Substance-related Disorders
- Nervousness
- Convulsions
- Catalepsy
- Muscle Rigidity
Interacting Proteins
- OPRM1
Pathways
- Secretion
- Methylation
- Dna Methylation
- Localization
- Parturition
- Synaptic Transmission
- Aging
- Neurogenesis
- Reflex
- Bone Development
- Response To Stress
- Lactation
- Neuroprotection
PTMs
- Methylation
- Cleavage
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PENK
bosterbio.com/bosterbio-gene-info-cards/PENK
References
PMID: 7057924 by Comb M., et al. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.
PMID: 6281660 by Noda M., et al. Isolation and structural organization of the human preproenkephalin gene.