PHD finger protein 19 Antibodies

Polycomb group (PcG) that specifically binds histone H3 trimethylated in'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: functions by binding to H3K36me3, a marker for transcriptional activation, and recruitment H3K36me3 histone demethylases RIOX1 or KDM2B, resulting in demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing.

Recruits the PRC2 complex to CpG islands and leads to embryonic stem cell self-renewal. Also binds dimethylated in'Lys- 36' (H3K36me2).