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- Table of Contents
Facts about PHD finger protein 19.
Recruits the PRC2 complex to CpG islands and leads to embryonic stem cell self-renewal. Also binds dimethylated in'Lys- 36' (H3K36me2).
Human | |
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Gene Name: | PHF19 |
Uniprot: | Q5T6S3 |
Entrez: | 26147 |
Belongs to: |
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Polycomblike family |
DKFZP727G051; hPCL3; MGC131698; MGC149712; MGC23929; MTF2L1; PCL3MGC149713; PHD finger protein 19; polycomb like 3; polycomb-like 3; Polycomb-like protein 3
Mass (kDA):
65.591 kDA
Human | |
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Location: | 9q33.2 |
Sequence: | 9; NC_000009.12 (120855651..120902160, complement) |
Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines.
Nucleus.
PMID: 15563832 by Wang S., et al. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers.
PMID: 21143197 by Boulay G., et al. Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.