PHKA2 Antibodies

AND PHKA2 ELISA kits, PHKA2 Proteins

Many biological assays use antibodies to detect PHKA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHKA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHKA2 antibodies...

We validate the specificity of these antibodies to PHKA2 by testing them on tissues known to express PHKA2 positively and negatively. Browse below to find the PHKA2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHKA2 Infographic by Boster Bio

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PHKA2 (NM_000292) Human Recombinant Protein

Coomassie blue staining of purified PHKA2 protein

$1249
Cat # PROTP46019
20 µg

PHKA2 Overview

Facts about Phosphorylase b kinase regulatory subunit alpha, liver isoform.

PHKA2 3D structure. Source: alphafold

Phosphorylase b kinase regulatory subunit alpha, liver isoform (PHKA2)

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

Gene Information

Human
Gene Name:	PHKA2
Uniprot:	P46019
Entrez:	5256

Family

Belongs to:

phosphorylase b kinase regulatory chain family

Alternative Names

GSD9A; MGC133071; PHK; PHKLA; phosphorylase b kinase regulatory subunit alpha liver isoform; phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase kinase alpha L subunit; phosphorylase kinase alpha-subunit; phosphorylase kinase, alpha 2 (liver); PYK; PYKL; XLG; XLG2

Molecular Weight

Mass (kDA):
138.408 kDA

Genomic Context


Human

Location:	Xp22.13
Sequence:	X; NC_000023.11 (18892298..18984114, complement)

Tissue Specificity

Predominantly expressed in liver and other non-muscle tissues.

Subcellular Localizations

Cell membrane; Lipid-anchor; Cytoplasmic side.

Diseases

Glycogen Storage Disease
Storage Disease
Hepatomegaly
Growth Retardation
Glycogen Storage Disease Type I
Glycogen Storage Disease, Type Ix
Liver Cirrhosis
Liver Diseases
Hypoglycemia
Glycogen Storage Disease Type Ii
Fasting Hypoglycemia
Liver Carcinoma

Glycogen Storage Disease Type Vi
Kidney Diseases
Proximal Renal Tubular Acidosis
Hypoglycemic Episode
Carcinoma
Fibrosis

Interacting Proteins

PHKG2

Pathways

Localization
Notch Signaling Pathway
Cell Division
Excretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHKA2

References

PMID: 7847371 by van den Berg I.E.T., et al. X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit.

PMID: 7549948 by Hirono H., et al. Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency.